Structure of PDB 8qsj Chain s Binding Site BS01

Receptor Information

>8qsj Chain s (length=386) Species: 9606 (Homo sapiens)

TPVARYPPIVASMTADSKAARLRRIERWQATVHAAESVDEKLRILTKMQF
MKYMVYPQTFALNADRWYQYFTKTVFLSGLPPPPAEPPALDLAALRAVAC
DCLLQEHFYLRRRRRVHRYEESEVISLPFLDQLVSTLVGLLSPHNPALAA
AALDYRCPVHFYWVRGEEIIPRGHRRGRIDDLRYQIDDKPNNQIRISKQL
AEFVPLDYSVPIEIPTIKCKPDKLPLFKRQYENHIFVGSKTADPCCYGHT
QFHLLPDKLRRERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWS
EADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQ
SKPLYETIEDNDVKGFNDDVLLQIVHFLLNRPKEEK

Ligand information

>8qsj Chain A (length=1418)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauaccaagcauaauau
agcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaa
cuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccu
aagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaaga
uuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguc
caagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaa
uccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggaca
cuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguagg
ccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaau
cccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacc
cuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccg
cauaagccugcgucagacacugaacugacaauuaacagcccaauaucuac
aaucaaccaacaagucauuauuacccucacugucaacccaacacaggcau
gcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuacc
ccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggca
ccgccgcuccacgaggguucagcugucucuuacuuuuaaccagugaaauu
gaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccua
uggagcuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguug
gggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuu
caccagucaaagcgaacacucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauagggcgaccucgauggaucaggacaucccgauggugcagccgcuauu
aaagguucguuuaacgauuaaaguccuacgugaucugaguucagaccgga
guaauccaggucgguuucuaucuacuuaaauuccucccuguacgaaagga
caagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauuc
ucaacuuaguauacccaccccacccaagaacaggguuuauauauauauau
auauauauauauauauau

<<<.......<<<<....................................
.<<....>>.........<.....<<.....>>....>........>>.>
>.............<<....>>..................>>>.......
....<<<.......>>>...<.<........>.>.<<<<<<.........
<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<
<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....
>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<
<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........
>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.
..<<<......>>>....<<<.<<<...<..............<....<<
<.........>>>....>.......<<<......>>>.............
..............>...>>>>>>........>>>>>>...<<<<<....
..>>>>>.........>>>>>><......<<..<<<....>>><<<<..<
<<<........<<<<<........>>>>>......<<<...<<<<.....
..................>>>>.......>>>.....<<......>>.>>
>>.....>>>>..<<<<...<<<<<<<<.<<................<<<
<<<..<<<.........>>>...<<<<<<.............>>>>>>..
..<<.>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>
.....<<<<<........>>>>>.......<<..<<<.<<<.....<<<<
.<<<<<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<.
....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.
....>>>>..>>>.....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<...<<<<<<<...<<.......>>...
>>>>>>>>>.>.....<<<<.<<<<<<..<<.<<<<<<......>>>>>>
...>>.<<<<<.>>>>>.....>>>>>..>...>>>>......<<<<<<<
....>>>.>>>>...>>>..>>>.>>...<<<.<<<..............
...>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.......
.....>>>.............<<<<.......>>>>.<<<<<<..>>>>>
>.<<<<<<<..>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qsj Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): A49 S50 T52 A53 D54 S55 K56 A57 R59 R62 W66 R81 I82 K85 M86 Q87 M89 Y94 T97 F98 R162 H164 R165 Y166 R219 G220 H221 R222 R223 R225 K270 P272 F274 Q277 K305 R310 R313
• Binding residue (residue number reindexed from 1): A11 S12 T14 A15 D16 S17 K18 A19 R21 R24 W28 R43 I44 K47 M48 Q49 M51 Y56 T59 F60 R115 H117 R118 Y119 R172 G173 H174 R175 R176 R178 K223 P225 F227 Q230 K258 R263 R266

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0006915 apoptotic process
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8qsj, PDBe:8qsj, PDBj:8qsj
• PDBsum: 8qsj
• PubMed: 38042949
• UniProt: Q9NP92|RT30_HUMAN Large ribosomal subunit protein mL65 (Gene Name=MRPS30)