Structure of PDB 8etc Chain s Binding Site BS01

Receptor Information

>8etc Chain s (length=30) Species: 4896 (Schizosaccharomyces pombe)

VSLKKKSKRRTTRLRSRIEKKAAESKRKQK

Ligand information

>8etc Chain 1 (length=2140)

auuugaccucaaaucagguaggacuacgcgcugaacucaauaagcgcagg
aaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcuc
aaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaa
gaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacg
ucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaa
gcgcuuucgaagagucgaguuguuugcagcucuaaauggguggucaucua
aagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaa
gaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaa
agggaagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaag
aauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggg
gacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaa
uggcccgucuacacggaccaaggagucuagcaucuaugcgaguguuuggg
ugaugaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccu
ggcgugcaccaucgaccgacccggaaggguuugaguaagagcauagcugu
ugggacccgaaagauggugaacuaugccugaauagggugaagccagagga
aacucugguggaggcucguuuggguauaggggcgaaagacuaaucgaacc
aucuaguagcugguuccugccgaaggcagaaacucagaucaguuuuaugu
guaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgau
gcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucag
acaccagaaaagguguuaguucaucuagacagcaggacgguggccaugga
agucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacua
gcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucug
gguuagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcaaauauucaaaugagaacuuugaagacugaaguggggaaagguucca
ugugaacagcaguuggacauggguuagucgauccuaagagauagggaagc
uccguaugaaaaucgaaagggaauccgguuaauauuccggaaccagaagg
uggaacacggcaacguaaaugaaguuggagacgucggcgggagcccuggg
aagaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuaucc
ggagcuaggguaugguguuuggaagaguucagcgccucaugcugaauccg
gugcgcucucgacggccuugaaaauccaacggaaguuucacaucuggucg
uacucauaaccgcagcaggucuccaaggugagccucuaguugauagaaca
auguagauaagggaagucggcaaaaugggaaucgauucccacugucccua
ucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucag
cgggguggcuuguggcagccaagcgcgacguugcuggcucuuccuaucau
accgaagcagaauucgguaagcguuggacccacuaauagggagcuggguu
ccuacugaugaagugucgucgcaaugguaauucaacuuaguacgagagga
accguugauucagaucauugguauuugcggcugccugacaaggcaaugcc
gcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauc
cgugccagaaagcgacgauuguauaaaaauagaggucucuccuguaucgu
agaagaugggcgaugguugaugaaacggaaguguuuuauugacuugucca
ugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauug
uaagcagcugcugagauuaagccuuuguucccaagauuug

..........................<<<<<<..........>>>>>.>.
........<<....>>..<<<<<......<<.>>.....>>>>>..<<<.
.<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....
<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.(
(......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>
>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>.
.>>>..................................<<....>>....
...........<<<<....>>>>...........................
.......<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......
.<<<<<<<......<...>......>>>>>>>.......>>>>>.>>>>>
>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>
>>..<<<<....>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<
<.......>>>>>..>>>...<<....>>........<<<<..<<<<<..
>>>>>...>>>>..<<<<<<<<....>>>.>>>.>>....>>>>>>.>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<..
..>>>>>>>.....>>>.>>>>>>>>>...<<.......>>......>>>
>>>......>.>>..<<<<<<....<<<<<<<<<<...<<<.<<<<<<..
>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...
.<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<
..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.....
....>>....>>.........<<......>>...>>>>>...>>>>>>>>
>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<.....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<....
.<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<
<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....
>>>.........>>....>>...<<<<<........>>>>>))<<<<..<
<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<
<<<<<....(..>>>>>>....<<<<<...<<<<<<....<<<.....>>
>....>>>>>>.....>>>>>.....<<<<<<<<.....>>>>>>>>>>>
>...>>>>>>>.>>>>........>>>>>>........>>>.>>>>>>>>
..>>.....<<......>>>>>>>.<<<<..>>>>..>>>>..<<<<...
..<<<<<<<.<<.........<.....<<<<<<>>>>>>...>..>>.>>
>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<
..<<.........<<<<<<...<..>...>>>>>><<<..<<<<<..<.<
<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>>>>>.....
.>>.>>>>>.....<<<<<<<<..<<<<.<.<<<<<..............
...>>>>>.><<<<<...<<<<...<<<<<<<<<<.)....>>>>..>>>
>>>..>>>>..>>>>>.<<<<....<<<<...........>>>>....>>
>>.>>>>....>>>>>>>>...<<.......<<<<..>>>>....>>...
.....<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>
>.........<<<<<.<.............>.....<<<<<<<<<.<<<.
...<<<..>>>...>>>....>>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8etc Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): L4 K5 K6 S8 K9 R10 R11 T12 T13 R14 L15 R16 S17 I19 E20 K21 K22 E25 K27 R28 K29
• Binding residue (residue number reindexed from 1): L3 K4 K5 S7 K8 R9 R10 T11 T12 R13 L14 R15 S16 I18 E19 K20 K21 E24 K26 R27 K28

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006364 rRNA processing
• GO:0015031 protein transport
• GO:0042254 ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus

External links

• PDB: RCSB:8etc, PDBe:8etc, PDBj:8etc
• PDBsum: 8etc
• PubMed: 36423630
• UniProt: O74791|GRN1_SCHPO GTPase grn1 (Gene Name=grn1)