Structure of PDB 8esq Chain s Binding Site BS01

Receptor Information

>8esq Chain s (length=32) Species: 4896 (Schizosaccharomyces pombe)

VSLKKKSKRRTTRLRSRIEKKAAESKRKQKRA

Ligand information

>8esq Chain 1 (length=2230)

uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaau
uugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaag
cugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucag
agagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgc
uuucgaagagucgaguuguuugcagcucuaaauggguggucaucuaaagc
uaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaug
aaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaaggg
aagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaagaaua
agggaagguggcuguuuauagcccuuguuguaauacguccacuggggacu
gaggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccg
ucuugaaacacggaccaaggagucuagcaucuaugcgaguguuuggguga
ugaaaacccauccgcgaaauggugaaugcaggugggaacgcccuuguggc
gugcaccaucgaccgguaagagcauagcuguugggacccgaaagauggug
aacuaugccugaauagggugaagccagaggaaacucugguggaggcucgu
uuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccug
ccgaaguuuccggauagcagaaacucagaucaguuuuaugaguauguaaa
augagaguuucuagugggccauuuuugguaagcagaacuggcgaugcggg
augaaccgaacgugagguuaaggugccggaauguacgcucaucagacgaa
aagguguuaguucaucuagacagcaggacgguggccauggaagucggaau
ccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccugaaa
auggauggcgcuuaagcguacuacccauaccucaccgucuggguuagcuu
ugagaagcucagacgaguaggcaggcguggagguuugugacgaagccuug
ggcgugagccugggucgaacagccucuagugcagaucuugguggaaguag
cauucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaa
cagcaguuggacauggguuagucgauccuaagagauagggaagcuccgua
ugaaaggcacgauuuuucgugccuaucgaaagggaauccgguuaauauuc
cggaaccagaagguggaaucaacacggcaacguaaaugaaguuggagacg
ucggcgggagcccugggaagaguucucuuuucuuuuuaacaaaccacacc
cugaaaucgguuuauccggagcuaggguaugguguuuggaagaguucagc
gaugcugaauccggugcgcucucgacggcccuugaaaauccaacggaagu
uguuuucacaucuggucguacuccuccaaggugccucuaguugauagaac
aauguagauaagggaagucggcaaaaugggaauucccacugucccuaucu
acuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucagcgg
cccuguugagcuugacucuaguuugacauuugucagguggggaguuaaag
uuaccacagggaucuuguggcagccaagcgcgacguugcuucggcucuuc
cuaucauaccgaagcagaauucgguaagcguuggacccacuaauagggaa
cgugagcugggaccgucgugagacgguuaguccuacugaugaagugucgu
cgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauu
gguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccg
gauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgau
uauguauaaaaauagagguaggcuacucuccuguaucguagaagaugggc
gaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccau
gaauccauugcauacgacuuuaauguggaacgggguauuguaagcagcug
cugagauuaagccuuuguucccaagauuug

........................<<<<<<........>>>>>.>.....
....<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<<.
......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<
<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((...
...<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>
>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>..>>>
..................................<<....>>........
.......<<<<....>>>>...............................
...<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<
<<<<......<...>......>>>>>>>>......>>>>>.>>>>>>>>>
>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<
<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<..
.....>>>>...>>>...<<.>>.......<<<<<..<<<<<.....>>>
>>...>>>>>.<<..>>....>>>>>>.>>>>>>..<<.<...<<<<<<.
..<<<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>.>
>>>>>>>>>><<.<....>.>>......>>>>>>......>.>>..<<<<
<<....<.<<..>>.><<<<<<<<<<...<<<.<<<<<<<....>>>>>>
>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<.
.....>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.....
.<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>...
.>>.........<<......>>...>>>>>...>>>>>>>>>>>>>....
......))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<......
......>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<
<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<
<.<<<<<<.......>>>>>><<<<.....<<<<..<<...<<<<<<...
..........>>>>>>....((<<<<<<...<<....<<<....>>>...
.....<<<<<<......>>>>>>..>>....>>...<<<<<........>
>>>>))<<<<..<<<<<<<....<<<....>>>.......<<<<<<...<
<<<.<<<<<<<<<<<<<<<<<<...((..>>>>>>....<<<<<...<<<
<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<
<.>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>......
.>>>>.>>>.>>>>>>>>..>>.>>>>.<<<..>>>..>>>>..<<<<..
...<<<<<<<.<<.........<....<<<<<>>>>>..>..>>.>>>>>
>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<.<<
<<<<<.<<<<<<<<<<<<<.<<<<<<<<..>>>>>>>>..>>>>>>.>>>
>>..>>>>>>>........<<<<<...<..>...>>>>>..<<<<...<<
<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>..
.....>>>>.<<<<<<<....>>>>>>>....>>.>>>>>.....<<<<<
<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<
<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<
<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>
.....<<.......<<<<..<..>..>>>>....>>........<<<<<.
...<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........
<<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>
>...>>>....>>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8esq Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): V2 L4 K6 K7 S8 K9 R10 R11 T12 T13 R14 R16 S17 S26 K29 R32 A33
• Binding residue (residue number reindexed from 1): V1 L3 K5 K6 S7 K8 R9 R10 T11 T12 R13 R15 S16 S25 K28 R31 A32

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006364 rRNA processing
• GO:0015031 protein transport
• GO:0042254 ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus

External links

• PDB: RCSB:8esq, PDBe:8esq, PDBj:8esq
• PDBsum: 8esq
• PubMed: 36423630
• UniProt: O74791|GRN1_SCHPO GTPase grn1 (Gene Name=grn1)