Structure of PDB 8cqw Chain s Binding Site BS01

Receptor Information
>8cqw Chain s (length=171) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSQNVMRELRIEKLVLNICVGESGDRLTRAAKVLEQLSGQTPVQSKARYT
VRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRSKNFSATGNFG
FGIDEHIDLGIKYDPSIGIYGMDFYVVMGRAGARVTRRKRARSTIGNSHK
TNKEDTIQWFKTRYDAEVLDK
Ligand information
>8cqw Chain 1 (length=3208) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuuugc
gguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaa
uguggcacggcuucugcuguguguuauagccucugacgauacugccagcc
uagaccgaggacugcgguuaccuaggauguuggcauaaugaucuuaaguc
gcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuug
gguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauu
agggugcaccaucgaccgauccugauguguucggauggauuugaguaaga
gcauagcuguugggacccgaaagauggugaacuaugccugaauaggguga
agccagaggaaacucugguggaggcucguagcgguucugacgugcaaauc
gaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuagua
gcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguu
uuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaa
cuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaac
guggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaa
cuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacg
cucaucagacaccacaaaagguguuaguucaucuagacagccggacggug
gccauggaagucggaauccgcuaaggaguguguaacaacucaccggccga
augaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuuc
accgugauugcuguuuugacgcuuucacgaguaggcaggcguggagguca
gugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagau
cuuggugguaguagcaaauauucaaaugagaacuuugaagacugaagugg
ggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaag
agauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucg
aaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggc
aacguaacugaauguggagacgucggcgugagcccugggaggaguuaucu
uuucuucuuaacagcuuaucacccuggaauugguuuauccggagaugggg
ucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacg
acgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguac
ucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaaua
auguagauaagggaagucggcaaaauagauccguaacuucgggauaagga
uuggcucuaaggaucgguuuaacgaucaacuuagaacugguacggacaag
gggaaucugacugucuaauuaaaacauagcauugugauggucagaaagug
auguugacacaaugugauuucugcccagugcucugaaugucaaagugaag
aaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaa
gguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaa
cgagauucccacugucccuaucuacuaucuagcgaaaccacagccaaggg
aacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacu
cuaguuugacauugugaaaagacauggaggguguagaauaagugggagcu
ucggccggugaaaccacuaccucuauaguuuuuuuacuuauucaaugaag
cggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgau
ccggguugaagacauugucagguggggaguuuggcuggggcggcacaucu
guuaaacgauaacgcagguguccuaagggggacucauggagaacagaaau
cuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugu
gaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaau
uugaggcuagaggugccagaaaaguuaccacagggauaacuggcuugugg
cagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcuc
uuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccac
uaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuu
acccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagagg
aaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgc
cgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaau
ccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacga
auaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuua
gcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcg
gggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagc
aguagaguagccuuguuguuacgaucugcugagauuaagcucuuguuguc
ugauuugu
.......................<<<<<<.....<......>......>>
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>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
.<.<<....>>...>...........<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<..<....
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....<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>
>>>>>>>........<<<.>>>.....>>>>>>>....>>>>>>>>>>>>
..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<
<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<...
.>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....
>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>
>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<
<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>
>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>
>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>
.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<
<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<...
.<<.........>>....>>.........<<......>>...>>>>>...
>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>
>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.
<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........
>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<
<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<
<....<<<....>>>..........<<<<<<....>>>>>>......>>.
...>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<..
..>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{.
.>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>
>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>
.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>
>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<...
..<<<<<<<.<<...............<<<<<....<....>.....>>>
>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............
<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>
>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<.
...>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>....
....<...........<<<<<.......>>>>>.....>.....>>....
>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<..
......>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<
<<.<<<<<<<<..<<<<<<<<<<...<.<<....................
....................>>.>...>>>>>>>>>>...<<<<<.....
<<<<..<<<<<......>>>>>..............<<<<...>>>>..>
>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<
<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>
>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......
>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>
>>))))))))))..........]]]]..}}]]]].......<<.<...<<
<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<
<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.
....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}
..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.............
....>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>
>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>
>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<......
....<<<......>>>......>>.......<<<<<<...<<<<<<<..<
<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>
>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<
<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>.
.>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cqw Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.05 Å
Binding residue
(original residue number in PDB)
K16 V18 N20 C22 S48 A50 R51 Y52 F57 I59 A66 H68 K94 N95 S97 A98 T99 G103 F104 G105 G124 M125 D126 Y128 K142
Binding residue
(residue number reindexed from 1)
K13 V15 N17 C19 S45 A47 R48 Y49 F54 I56 A63 H65 K91 N92 S94 A95 T96 G100 F101 G102 G121 M122 D123 Y125 K139
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