Structure of PDB 8ch6 Chain s Binding Site BS01

Receptor Information
>8ch6 Chain s (length=165) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIF
KELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGPDYPPNYILF
LNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAAR
DALQGFKAMKITYAK
Ligand information
>8ch6 Chain f (length=137) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuggcuaagaucaaguguaguaucuguucuuaucagu
uuaauaucugauguccucucgaggacggauuuuuggagcagggagccacg
caucgaccugguauugcaguaccuccaggaacggugc
.............................................<<<..
........>>>...<<<<..>>>>.................<......><
<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB8ch6 Structural basis of catalytic activation in human splicing.
Resolution5.9 Å
Binding residue
(original residue number in PDB)		Y10 N12 N13 D16 V41 A42 L43 K44 K47 R49 G50 F53 A84 K85 S88
Binding residue
(residue number reindexed from 1)		Y4 N6 N7 D10 V35 A36 L37 K38 K41 R43 G44 F47 A78 K79 S82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005685 U1 snRNP
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ch6, PDBe:8ch6, PDBj:8ch6
PDBsum8ch6
PubMed37165190
UniProtP08579|RU2B_HUMAN U2 small nuclear ribonucleoprotein B'' (Gene Name=SNRPB2)

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