Structure of PDB 7ow7 Chain s Binding Site BS01

Receptor Information
>7ow7 Chain s (length=139) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMP
FKCMQLTDFILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERK
AKMTDFDRFKVMKAKKMRNRIIKNEVKKLQKAALLKASP
Ligand information
>7ow7 Chain A (length=3303) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccggggggcccaaguccuucugaucgaggcccag
cccguggacggugugaggccgguagcggcccccggccgggucuucccgga
gucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaa
ggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaag
uugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaaga
gguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcgg
cggguccggccgggcggaucugaccgucggcgaccggccgccgccgggcg
cauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaag
gcccggcggggaagguggcucggccgaguguuacagcccccccggcagca
gcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccug
ggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguc
cccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgc
gcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcu
acccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgc
gagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggcc
ggccgaggugggaucccgaggccucucgccgagggcgcaccaccggcccg
ucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacc
cgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucug
guggagguccguagcgguccugacgugcaaaucggucguccgaccugggu
auaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaag
uuucccucaggauagcuggcgcucucggcaguuuuauccgguaaagcgaa
ugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcuc
gcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuug
guaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcc
cgaugccgacgcucaucagaccccagaaaagguguugguugauauagaca
ggaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauac
ccggccgucgccggcaguccgcggacgcuacgccgcgacgaguaggaggg
ccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgcc
gcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuuga
aggccgaaguggagaaggguuccaugugaacagcaguugaacauggguca
gucgguccugagagaugggcgagcgccguuccgaagggggccgaucgaaa
gggagucggguucagauccccgaauccggagcggagaugggcgccgcgag
gcguccagugcgguaacgcgaccgaucccggagaagccggcgggagcccc
ggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguu
cgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggc
guccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaa
ucucgcgccgggccguaccuauauccgcagcaggucuccaaggugaacag
ccucuggcauguuggaacaauguagguaagggaagucggcaagccggauc
cguaacuucgggauaaggauuggcucuaagggcuagccgacuuagaacug
gugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaag
gcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaug
ucaaagugaagaaauucaaugaagcgcggguaaacggcgggagcucucuu
aagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaug
aacgagauucccacugucccuaccuacuauccagcgaaaccacagccaag
ggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuuga
cucuagucuggcacggugaagaguuuuucacugacccggugaggcggggg
gcgcuucuggcgccaagcgcccggccgggcgcgacccgcuccggggacag
ugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgc
agguguccuaaggcgagcucagggaggacagaaaccucccguggagcaga
agggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccguga
aagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggug
ucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucau
agcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauuguga
agcagaauucaccaagcguuggauuguucacccacuaauagggaacguga
gcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaug
uguuguugccaugguaauccugcucaguacgagaggaaccgcagguucag
acauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccau
cugugggauuaugacugaacgccucuaagucagaaucccgcccaggcgga
acgauacggcagcgccgcggagccucgguuggccucggauagccgguccc
cgggguccggugcggagugcccuucguccugggaaacggggcgcggccgg
agaggcggccgcccccucgcccgucacgcaccgcacguucguggggaacc
uggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacgu
agcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguu
ugu
.........................<<<<<<.....<......>......
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..>>>>...<<<<<<<<<.<<<<<<<<....<<<<......>>>>.....
((......<<<.....))>>>...>.>>>>>>>....>>>>>>>>>....
...<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..
>>>..................................<<....>>.....
..........<<<<....>>>>............................
......<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<
<<<..<<<<<<..<<<<.<<.>>>>>>.>>>...>>>>>>>>>>>>>>..
....>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..
<<<....<<<<......<<<<<..>>>>>.......>>>>...>>>....
....>>>>>>..>>>>>>>>>>>............<<<<<..<<<<<<..
>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<<<<<<<<.<<<<..
..>>>>.>>>>>>>>>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<
<<<<<<..>>>>>.>>.....>>>>>......>>.>>>>>....>>>>..
.>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<
..<<<...<<<<........>>>>.....>>>...<<....>>...<<<.
.>>>..<<<<<...<<<..<<<.....>>>..>>>....>>>>>.<<<<<
<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<
.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>
>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>
>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....
<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....
<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<
.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<
.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((
.......<<<<<.....<<..........<<<.<<<<<<<<<<.......
...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>
>>>>><<<<<<.<<<................>>>>>>>>>....>>>>>>
...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>
>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>
>.<<<.....<<<<<<<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<<<...<<....<<<....>>>.................>>....
>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>
>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<
<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<..
...>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>
>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........
>>.>>>.>>>>.>>>..>>>....<<......>>>>>>>.<<<<.....>
>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<
<...............>>>>><<.<<<<<<<<<..>>>..>>>>>>.>>.
...........<<<<<<<<<..<<<.........>>>..<<<<<<<....
<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<
<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<..>>>>..
......<...........<<<<<.......>>>>>.....>.....>>..
..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<
........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<
<<<<.<<<<<<<<<.<<<<<<<..>>>>>>>...<<<<<.....<<<<..
................<<<<<<<..>>>>>>>..>>>>..>>>>>....>
>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>
>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.
(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<..
..>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>..
.......>>>>..>>>>>>.......<<.<...<<<<<<...<<......
.>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<
<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...
>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....
.<<<<<<.<..<<<....<<<<<.................>>>>>..<<<
<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>
>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>
>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<
..>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<.
.....>>>>>>>>>>>...>>>>..>>>..............>>>>..>>
.>>>>>><<<<<.<.............>..<<.<<<<<<<.<<.....<<
<<.<..<<<<..>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>
>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ow7 Structure of human EIF6-bound large ribosomal subunit
Resolution2.4 Å
Binding residue
(original residue number in PDB)
V2 F3 R4 R5 S16 F17 P19 H20 D29 N34 Q44 V45 R46 K53 Q56 P65 H66 H69 Q70 K71 Y72 R90 W91 K94 R98 K101 M113 K114 K117 M118 N120 R121 N125 K129 K132
Binding residue
(residue number reindexed from 1)
V1 F2 R3 R4 S15 F16 P18 H19 D28 N33 Q43 V44 R45 K52 Q55 P64 H65 H68 Q69 K70 Y71 R89 W90 K93 R97 K100 M112 K113 K116 M117 N119 R120 N124 K128 K131
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7ow7, PDBe:7ow7, PDBj:7ow7
PDBsum7ow7
PubMed
UniProtQ6IPH7

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