Structure of PDB 7ase Chain s Binding Site BS01

Receptor Information
>7ase Chain s (length=295) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDKRQQRFLAACLGVTTWDGRDVCFYEEKLPKENDVVWVKVIQVNDTSAV
VQLLEYGNHEGIIPYTEITRIRIRAIGKVIKVGRNEAAQVIRIDKEKGYI
DLSKKQVTLKEAKECEARFLKGNEVRSIVCHVADECGIPAAQAMEMIAYP
LYRRQPGKHAWDWLHELNRNRDVEGILGPLHLPEKAQKLLLATLEHTVRN
DTATIHADIEMTCFQCDGVNALRDVLLLGRRFKADQEPQIPISVTIVGPP
RYRLRAKTEEREEGMRRMRETIETMAIEIAKRGGILRVVHGPYAL
Ligand information
>7ase Chain 1 (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcaccguggcgcaguggaagcgcgaugggcucauaacccauaggacguu
ggaucgaaaccaaccggugcuacca
<<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB7ase Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Resolution3.33 Å
Binding residue
(original residue number in PDB)		K104 R108 W119 G121 R122 K179 K182 R185 H232 E296 H297 V348
Binding residue
(residue number reindexed from 1)		K3 R7 W18 G20 R21 K78 K81 R84 H131 E195 H196 V247
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0033290 eukaryotic 48S preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ase, PDBe:7ase, PDBj:7ase
PDBsum7ase
PubMed33357443
UniProtQ4E620

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