Structure of PDB 6vlz Chain s Binding Site BS01

Receptor Information

>6vlz Chain s (length=393) Species: 9606 (Homo sapiens)

PVARYPPIVASMTADSKAARLRRIERWQATVHAAESVDEKLRILTKMQFM
KYMVYPQTFALNADRWYQYFTKTVFLSGLPPPPAEPEPEPEPEPEPALDL
AALRAVACDCLLQEHFYLRRRRRVHRYEESEVISLPFLDQLVSTLVGLLS
PHNPALAAAALDYRCPVHFYWVRGEEIIPRGHRRGRIDDLRYQIDDKPNN
QIRISKQLAEFVPLDYSVPIEIPTIKCKPDKLPLFKRQYENHIFVGSKTA
DPCCYGHTQFHLLPDKLRRERLLRQNCADQIEVVFRANAIASLFAWTGAQ
AMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPR
KNICWGTQSKPLYETIEDNDVKGFNDDVLLQIVHFLLNRPKEE

Ligand information

>6vlz Chain A (length=1527)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccca
cuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauugga
ccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaa
acauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaa
uuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacu
gucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaag
gaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagc
aucaccaguauuagaggcaccgccugcccagugacacauguuuaacggcc
gcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauag
ggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaac
cagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacga
gaagacccuauggagcuuuaauuuauuaaugcaaacaguauaccaaaccu
gcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccga
gcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaa
uaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuau
ucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucagg
acaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaa
aguccuacgugaucugaguucagaccggaguaauccaggucgguuucuau
cuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuac
uucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuau
acccacacccacccaagaacaggguuu

<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>...<<<......>>>....<<<.<<<...<..............<..
...<<.........>>.....>.......<<<......>>>.........
...........................>...>>>>>>........>>>>>
>...<<<<<......>>>>>.........>>>>>><......<<..<<<.
...>>><<<<..<<<<........<<<<<..............>>>>>..
....<<<...<<<<.......................>>>>.......>>
>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<
................<<<<<<..<<<.........>>>...<<<<<<..
...........>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><
<<<<<......>>>>>>........<...........<<<<<<.....>>
>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>
>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<
......<<<<.<<<<<<..<<<<..<<<<<<<<.....<..>.......>
>>>>>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>
..<......<<<..<<<<.....>>>>..>>>.....>.........<<<
....>>>............>>>>..>>>>>>.......<<<..<<<<<<<
<...<<.......>>...>>>>>>>..>.>>.>.......<.<<<.<<<<
<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>....
.>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>
>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<
<<....>>>.>>>>>......<<<................>>>......>
..........<<<<.......>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6vlz Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
• Resolution: 2.97 Å
• Binding residue (original residue number in PDB): A49 S50 T52 S55 R62 R65 W66 R81 K85 M86 Y94 T97 F98 R162 V163 R165 Y166 R219 G220 H221 R223 R225 P272 F274 Q277 D304 R310
• Binding residue (residue number reindexed from 1): A10 S11 T13 S16 R23 R26 W27 R42 K46 M47 Y55 T58 F59 R123 V124 R126 Y127 R180 G181 H182 R184 R186 P233 F235 Q238 D265 R271

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0006915 apoptotic process
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6vlz, PDBe:6vlz, PDBj:6vlz
• PDBsum: 6vlz
• PubMed: 32737313
• UniProt: Q9NP92|RT30_HUMAN Large ribosomal subunit protein mL65 (Gene Name=MRPS30)