Structure of PDB 5ool Chain s Binding Site BS01

Receptor Information
>5ool Chain s (length=370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VARYPPIVASMTADSKAARLRRIERWQATVHAAESVDEKLRILTKMQFMK
YMVYPQTFALNADRWYQYFTKTVFLSGLPAALRAVACDCLLQEHFYLRRR
RRVHRYEESEVISLPFLDQLVSTLVGLLSPHNPALAAAALDYRCPVHFYW
VRGEEIIPRGHRRGRIDDLRYQIDDKPNNQIRISKQLAEFVPLDYSVPIE
IPTIKCKPDKLPLFKRQYENHIFVGSKTADPCCYGHTQFHLLPDKLRRER
LLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAV
ITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYETIEDNDV
KGFNDDVLLQIVHFLLNRPK
Ligand information
>5ool Chain A (length=1441) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaau
ggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugacc
ugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugga
gcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggcg
accucggagcagaacccaaccuccgagcaguacaugcuaagacuucacca
gucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguua
cccuagggauaacagcgcaauccuauucuagaguccauaucaacaauagg
guuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuau
uaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucaga
ccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaa
aggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaug
auaucaucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<..............<....<<<.........>>>....>.....
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>><.
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
>..........<...........<<<<<<.....>>>>>>.....>....
>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>....
.<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<
<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>
>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>
>>>..>>>....>>.........<<<....>>>............>>>>.
.>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>
...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>
>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<
<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<..........
.......>>>.>>><<<<<...<<<....>>>.>>>>>......<<<...
.............>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ool Structures of the human mitochondrial ribosome in native states of assembly.
Resolution3.06 Å
Binding residue
(original residue number in PDB)
A49 S50 T52 A53 D54 S55 K56 A57 R59 R62 R65 W66 R81 I82 K85 M86 Q87 F88 M89 Y94 T97 F98 R160 R162 H164 R165 Y166 R219 G220 H221 R222 R223 R225 K270 P272 F274 R276 Q277 D304 K305 R307 R310 R313
Binding residue
(residue number reindexed from 1)
A9 S10 T12 A13 D14 S15 K16 A17 R19 R22 R25 W26 R41 I42 K45 M46 Q47 F48 M49 Y54 T57 F58 R100 R102 H104 R105 Y106 R159 G160 H161 R162 R163 R165 K210 P212 F214 R216 Q217 D244 K245 R247 R250 R253
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0006915 apoptotic process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5ool, PDBe:5ool, PDBj:5ool
PDBsum5ool
PubMed28892042
UniProtQ9NP92|RT30_HUMAN Large ribosomal subunit protein mL65 (Gene Name=MRPS30)

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