Structure of PDB 8etg Chain r Binding Site BS01

Receptor Information

>8etg Chain r (length=154) Species: 4896 (Schizosaccharomyces pombe)

PQNEYIEESIRKHGRRFDHEERKRKKAAREAHDASLYAQKTRGIKAKLYQ
EKRRKEKIQMKKTIKQHKRMITKATFVFIRPMALRQKKANVTHKELGVTM
QLPIIGVKKNPQSPTYTQLGVLTKGTVIEVNVSELKYAQITNNPELDGCV
NALL

Ligand information

>8etg Chain 1 (length=2018)

uugaccucaaaucagguaggacuacgcgcugaaaauaagcgcaggaaaag
aaaauaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuu
gaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcu
gcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagag
agggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuu
ucgaagagucgaguugugcagcucuaaauggguggucaucuaaagcuaaa
uauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaa
gaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagc
auuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaaggg
aagguggcuguuuauagcccuuguuguaauacguccacuggggacugagg
acugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgu
ccacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaac
ccauccgcgaaaugaaagugaggugggaacgcccuuguggcgugcaccau
cgaccguaagagcauagcuguugggacccgaaagauggugaaaccaucua
guagcugguuccugccgaaguuucccucaggauagcagaaacucagauca
guuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaag
cagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaau
guacgcucaucagaagaaaagguguuaguucaucuagacagcaggacggu
ggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccg
aaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccu
caccgucuggguuaggaagcucagacgaguaggcaggcguggagguuugu
gacgaagccuugggcgugagccugggucgaacagccucuagugcagaucu
ugguggaaguagcuucaaaugagaacuuugaagacugaaguggggaaagg
uuccaugugaacagcaguuggacauggguuagucgauccuaagagauagg
gaagcuccguaugaaaggcacgauuuuucgugccuaucgagggaauccgg
uuaauauuccggaaccagaagguggaauacggcaacguaaaugaaguugg
agacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaacc
auuacccugacuaggguaugguguuuggaagaguucagcgccucaugcug
aauccggugcgcucucgacggccaaaauccaacggaaguuuucacaucug
gucguacucuccaaggugaacagccucuaguugauagaacaauguagaua
agggaagaaugggcccacugucccuaucuacuaucuagcgaaaccacagc
cuggggggccaggcaaaaucagcggcuuguggcagccaagcgcgacguug
cucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaccca
cuaauagggaacgugagcuggccuacugaugaagugucgucgcaauggua
auucaacuuaguacgagaggaaccguugauucagaucauugguauuugcg
gcugccugacaaggcaaugccgcggagcuaucaucugcuggauaacggcu
gaacgccucuaagccagaauccgugccagaaagcgacgauuuguauaaaa
auagagguaggcuacucuccuguaucguagaagaugggcgaugguugaug
aaacggaaguguuuuauugacuuguccaugaaauuccagaauccauugca
uacgacuuuaauguggaacgggguauuguaagcagcugcugagauuaagc
cuuuguucccaagauuug

........................<<<<<<.......>>>>>.>......
...<<....>>..<<<<<......<..>.....>>>>>..<<<..<<...
....<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.
<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((.....
.<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.
>>........<<<<<<..>>>>>>.....<<<<<..>>>>>..>>>....
..............................<<....>>............
...<<<<....>>>>..................................<
<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<........<<<<<<<
.................>>>>>>>.......>>>>>.>>>>>>>>>>...
.....<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<
..>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>
>>...>>>...<<....>>..<<<<<..<<<<<.....>>>>>...>>>>
>.<<.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...>>>>>>..
....>.>>..<<<<<<....<..<<....>>..><<<<<<<<<<...<<<
.<<<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....
>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....
<<<<<<.....<<......<<<.<<<<<<<<<<.......<<<<<.<<..
..<<.........>>....>>.........<<......>>...>>>>>..
.>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>
>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<
......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>
>>>><<.....<<<<<<<<.......>>>>>><<<<.....<<<...<<.
..<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<
<....>>>........<<<<<<......>>>>>>..>>..>>...<<<<<
........>>>>>))<<<<..<<<<...<<<....>>>.......<<<<<
<...<<<<.<<<<<<<.<<<<<<<<<<.......>>>>>>....<<<<..
..<<<<<<<..>>>>>>>.....>>>>.....<<<<<<<<.....>>>>>
>>>>>>>...>>>>>>>.>>>>.....>>>>>>......>..>>>.>>>>
>>>>..>>.>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<
.<<.......<<..>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<....>>>>>....<<<<<.<.......<<<<<...<..>...>>>>
>.<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>
.....>>>>.......>>>>...>.>>>>>......<<<<<<<..<<<<.
<.<<<<<.................>>>>>.><<<<<...<<<<....<<<
<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<
...........>>>>....>>>>.>>>>....>>>>>>>.....<<....
...<<<<<.<..>>.>>>>....>>........<<<<<....<<<<<<<<
<<<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.....
........>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>
>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8etg Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): P2 Q3 E5 Y6 I7 E8 R23 K26 R30 H33 S36 Q40 T42 R43 I45 K48 L49 Q51 R54 K58 I59 K63 N182 V190 T191 Q193 T245
• Binding residue (residue number reindexed from 1): P1 Q2 E4 Y5 I6 E7 R22 K25 R29 H32 S35 Q39 T41 R42 I44 K47 L48 Q50 R53 K57 I58 K62 N90 V98 T99 Q101 T141

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0000460 maturation of 5.8S rRNA
• GO:0000470 maturation of LSU-rRNA
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0030687 preribosome, large subunit precursor
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8etg, PDBe:8etg, PDBj:8etg
• PDBsum: 8etg
• PubMed: 36423630
• UniProt: Q9UU79|NSA2_SCHPO Ribosome biogenesis protein nsa2 (Gene Name=nsa2)