Structure of PDB 7oi7 Chain r Binding Site BS01

Receptor Information

>7oi7 Chain r (length=146) Species: 9606 (Homo sapiens)

FREVVETTIIEGRITATPKESPNPPNPSGQCPICRWNLKHKYNYDDVLLL
SQFIRPHGGMLPRKITGLCQEEHRKIEECVKMAHRAGLLPNHRPRQLNRY
LTRWAPGSVKPIYKKGPRWNRVRMPVGSPLLRDNVCYSRTPWKLYH

Ligand information

>7oi7 Chain A (length=1054)

gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucaguacaugcuaagacuucaccagucaaagcgaaccuca
auugauccaauaacuugaccaacggaacaaguuacccuaggguaucuacu
uuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaa
gcgccuucuaaaugauaucaucucaacuuaauacccacacccaagaacag
gguu

<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>......>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>..
.......<<<....>>>............>>>>..>>>>>>>..>>>.>>
..<<<.<<<.................>>>.>>><<<<<...<<<....>>
>.>>>>>.<<<.<............>.>>>........<<<<.......>
>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oi7 A distinct assembly pathway of the human 39S late pre-mitoribosome.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): N82 R94 M99 P101 R102 K120 H123 R124 R132 P133 Y150 L151 R153 W154 A155 S158 K164 K165 G166 R168 P179 R182 S188 R189 W192 K193 Y195 H196
• Binding residue (residue number reindexed from 1): N43 R55 M60 P62 R63 K81 H84 R85 R93 P94 Y100 L101 R103 W104 A105 S108 K114 K115 G116 R118 P129 R132 S138 R139 W142 K143 Y145 H146

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0070181 small ribosomal subunit rRNA binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oi7, PDBe:7oi7, PDBj:7oi7
• PDBsum: 7oi7
• PubMed: 34315873
• UniProt: Q9NVS2|RT18A_HUMAN Large ribosomal subunit protein mL66 (Gene Name=MRPS18A)