Structure of PDB 7of6 Chain r Binding Site BS01

Receptor Information

>7of6 Chain r (length=157) Species: 9606 (Homo sapiens)

FREVVETQEGKTTIIEGRITATPKESPNPPNPSGQCPICRWNLKHKYNYD
DVLLLSQFIRPHGGMLPRKITGLCQEEHRKIEECVKMAHRAGLLPNHRPR
LPKSKPQLNRYLTRWAPGSVKPIYKKGPRWNRVRMPVGSPLLRDNVCYSR
TPWKLYH

Ligand information

>7of6 Chain A (length=1463)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacauaaaguauaggcgauagaaauugauggcgcaauagauauag
uaccgcaagggaaagaugaaaaaccaagcauaauauagcaaggacuaacc
ccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagag
ccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaa
gagcacacccgucuauguagcaaaauagugggaagauuuauagguagagg
cgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuu
aguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacgu
uuaacggccgcgguaccgugcaaagguagcauaaucacuuguuccuuaaa
uagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuu
aaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaaga
cgagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaa
aaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguac
augcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuug
accaacggaacaaguuacccuagggauaacagcgcaauccuauucuagag
uccauaucaacaauaggguuuacgaccucgauguuggaucaggacauccc
gauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccua
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
aauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaag
cgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacc
caagaacaggguu

<<<.......<<<<.................................<..
....>...........<<.....>>.........>>.>>...........
..<<....>>................>>>...........<<<.......
>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....
>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<....
.>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<
.......>>......>.>>>>......>.>>..<<<<<<....<<<<...
.>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<................<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<..<<<<<..>>
>..>>>>><<<<<..>>>>>........<...........<<<<<<....
.>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>
>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<
.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
..<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>
............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.
......>>...>>>>>>...>.>>.>.........<<<.<<<<<<..<<.
<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>.
.>...>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>..
.<<<.<<<.................>>>.>>><<<<<...<<<....>>>
.>>>>>......<<<................>>>.............<<<
<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of6 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): N82 R94 H96 G98 M99 P101 R102 H112 E116 K120 H123 R124 R132 P133 P141 K142 K144 Y150 L151 R153 W154 A155 S158 K160 Y163 K165 R168 R171 R173 R182 R189 W192 K193 Y195 H196
• Binding residue (residue number reindexed from 1): N48 R60 H62 G64 M65 P67 R68 H78 E82 K86 H89 R90 R98 P99 P102 K103 K105 Y111 L112 R114 W115 A116 S119 K121 Y124 K126 R129 R132 R134 R143 R150 W153 K154 Y156 H157

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0070181 small ribosomal subunit rRNA binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of6, PDBe:7of6, PDBj:7of6
• PDBsum: 7of6
• PubMed: 34135319
• UniProt: Q9NVS2|RT18A_HUMAN Large ribosomal subunit protein mL66 (Gene Name=MRPS18A)