Structure of PDB 6fec Chain r Binding Site BS01

Receptor Information
>6fec Chain r (length=124) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDE
PMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSC
VVVKDYGKESQAKDVIEEYFKCKK
Ligand information
>6fec Chain A (length=1776) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagcggcggcg
gcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcgg
cgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccg
ugccuaccauggugaccacgggugacggggaaucaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccacucccgacccggggagguagugacgaaaaauaacaauaca
ggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuua
acgaggauccauuggagggcaagucuggucgcagcagccgcgguaauucc
agcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguug
gaucuugagggcccgccccucggcgcccccucgaugugucccgcggggcc
cgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccg
ccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuug
uugguuuucggaacugaggccaugauuaagagggacggccgggggcauuc
guauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccag
agcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgg
agguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugcc
gacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgg
gaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaac
uuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaa
uuugacucaacacgggaaaccucacccggcccggacacggacaggauuga
cagauugauagcucuuucucgauucugugggugguggugcauggccguuc
uuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacuc
uggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggc
ucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccc
cauucgugauggggaucggggauugcaauuauuccccaugaacgaggaau
ucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuu
guacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccuc
ggaucggcccgccggggucggcccacggcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccg
uaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((................[[[.
[[[...<....<.....<<..........>>....>.>.......{{...
.....[[[.{..........[[[[[..................<<.....
<<..<.......>..>>......>>..........<<...<<........
..>>...>>..[[..(((((.......<<<<<<<<<<.<........>>>
>..............)))))......]]...<<<...<<......>>...
>>>.]].]]].......}.]]].<<<....<<<.....<<<<<<......
...>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.}
}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]]....
.....<<<....<<<.....>>>..>>>...............<<<.<<<
<<.<<<....>>>.>.>>>>..>>>......<..................
.>.........<<<<<((......<<<<.........)).........>>
>>.>>>>>..)))))).]]]............<<.......{{...[[[.
[[....<.<..>.>..........<<<<<...............>>>>>.
........<<<<<..........<<..............<<<.......>
>>....>>.........>>..>>>.......[[....[.(((((.....>
>>>>>>...))))).]...]]....]]....<<<<<<..<...<<<<..<
<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>......
.<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<
.....<...<<.............>>...>..>>>>>..........<<<
.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<
..>>>>...>>.....>>>......<<......<<<......>>>....>
>...]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<....
..<<........>>..........<<<<<.......<<<<<.......<<
.<<<........>>>.>>.....>>>>>....<..<<<....<<<<<<..
...<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<
.......<<<<..<<<<.......<..<<<....>>>>........>>>>
..>>>>........<<<<<.....>>>>>........>>>.....>>.>>
>...>...>>>.>......>>>>>...>>.>>>>.>>>.....<<.<<<.
.......<.......<<<.<<<<....>>>>.>>>....>.........>
>>.>>..........<.<<<<<..........>>>>>>..........>>
>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>
>>.>>.......<<.....<<<.<<....<<<<<<<<.<<...<<<<..<
...<<<<<<<<<<<<<<...........>>>>>>>>>...>>>>>...>.
.>>>>...>>.>>>>>>>>...>>.>>>......>>.........<<<<<
<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fec Structure of a human cap-dependent 48S translation pre-initiation complex.
Resolution6.3 Å
Binding residue
(original residue number in PDB)		R33 G34 I35 R36 E37 K40 C56 D57 Y61 N82 L91 R96 E97 G98 K99 P100 R101 K102 V104 G105 C106 S107
Binding residue
(residue number reindexed from 1)		R25 G26 I27 R28 E29 K32 C48 D49 Y53 N74 L83 R88 E89 G90 K91 P92 R93 K94 V96 G97 C98 S99
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0043231 intracellular membrane-bounded organelle
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6fec, PDBe:6fec, PDBj:6fec
PDBsum6fec
PubMed29401259
UniProtP25398|RS12_HUMAN Small ribosomal subunit protein eS12 (Gene Name=RPS12)

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