Structure of PDB 6zvk Chain q2 Binding Site BS01

Receptor Information

>6zvk Chain q2 (length=147) Species: 9986 (Oryctolagus cuniculus)

PSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPG
YFGKVGMRHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPII
DVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKGVGGACVLVA

Ligand information

>6zvk Chain e2 (length=3920)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgccccccguggggucggcgggggaccguccccc
gaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
gggccccgcgggaccgaaaccccccccgaguguuacagcccccccggcag
cagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcu
cuccccccucccggcgcccacccggggcgcgccggcgucuccucgugggg
gggccgggccaccccucccacggcgcgaccgcucucccaccccucgucgg
ggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgg
gcccgggggagguucucucggggccacgcgcgcgucccccgaagaggggg
acggcggagcgagcgcacggggucggcggcgacgucggcuacccacccga
cccgucuugaaacacggaccaaggagucuaacacgugcgcgagucggggg
cucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucg
ccggccgaggugggaucccgaggccucuccaguccgccgagggcgcacca
ccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacgug
uuaggacccgaaagauggugaacuaugccugggcagggcgaagccagagg
aaacucugguggagguccguagcgguccugacgugcaaaucggucguccg
accuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucc
cuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcacc
cccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggc
cgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggc
ucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuug
guaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcc
cgaugccgacgcucaucagaccccagaaaagguguugguugauauagaca
gcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaac
ucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgg
gcccauacccggccgucgccggcagucgagaguggacgggagcggcgggg
gcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcg
acgaguaggagggccgcugcggugagccuugaagccuagggcgcgggccc
ggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaa
acgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcagu
ugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagg
gacgggcgauggccuccguugcccucggccgaucgaaagggagucggguu
cagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagu
gcgguaacgcgaccgaucccggagaagccggcgggagccccggggagagu
ucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgag
agaggggcccgugccuuggaaagcgucgcgguuccggcggcguccgguga
gcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgcc
gggccguacccauauccgcagcaggucuccaaggugaacagccucuggca
uguuggaacaauguagguaagggaagucggcaagccggauccguaacuuc
gggauaaggauuggcucuaagggcugggucggucgucggccggcgccuag
cagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaa
aacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucu
gcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaa
acggcgggaguaacuaugacucucuuaagguagccaaaugccucgucauc
uaauuagugacgcgcaugaauggaugaacgagauucccacugucccuacc
uacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcg
gggaaagaagacccuguugagcuugacucuagucuggcacggugaagaga
caugagagguguagaauaagugggaggcccccggcgcccccccggugucc
ccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaa
auaccacuacucugaucguuuuuucacugacccggugaggcgggggggcg
agccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccgg
ccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggg
gcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucaggg
aggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuug
auuuucaguacgaauacagaccgugaaagcggggccucacgauccuucug
accuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaa
cuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuuc
gaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggau
uguucacccacuaauagggaacgugagcuggguuuagaccgucgugagac
agguuaguuuuacccuacugaugauguguuguugccaugguaauccugcu
caguacgagaggaaccgcagguucagacauuugguguaugugcuuggcug
aggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccu
cuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagcc
ucgguuggccucggauagccggucccccgccuguccccgccggcgccgcg
cgccgggaccgggguccggugcggagugcccuucguccugggaaacgggg
cgcggccggagaggcggccgcccccucgcccgucacgcaccggccguucg
uggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucggg
guuucguacguagcagagcagcucccucgcugcgaucuauugaaagucag
cccucgacacaaggguuugu

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<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
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>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>..................................<<<<<<<<..<<<..
....<<<<<<<<.<<<.....<<<<<<<<<<<...<<<.....<<<<.<<
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>>.......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<
<<..<<<<<<<<<<.<<<....<.....<<<<.<<<<......<<<<<<<
.<....<..>...........>>..>>>>>>.......>>>>.>>>>...
.......>.>>>...>>>>>>>>>>....................<<<<.
..<<<<<<<..<<<<<....<<<.>>>..>>>>>.<<......>>.>>>>
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>>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>
>...>.>>>...........>.>.........<<<<<<<<.....>>>>>
>>>.........>>>>.......>>.>>>>>....>>>...>>>>>>>>.
.<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<
<<........>>>>.....>>>...<<....>>...<<<<<<<......>
>>>>>>..<<<<<...<<<..<<<...(((..[..>>>..>>>....>>>
>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>
>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<.
...>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>...
.>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<
<<<<....<.<<<....>>>.><<<<<<<<<<..................
.........<<.<<<<<<<<<...<<<....<<<..<.<<<..<....<.
........>...>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<
<<........>>>>>>>>>...>>.>>>>>>>>>.>>>..<<<<.<<<<<
.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((
.......<<<<<.....<<..........<<<.<<<<<<<<<<.......
<<....<<....<<.........>>....>>.......<.<<......>>
.>....>>...>>>>>>>>>>>>>..........))).>>...>>>>>..
>>>...>>>>>>><<<<<<.<<<............].)))..........
............................................>>>>>>
>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>
>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<
<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....
>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........
<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<..
......>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..
<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<.
.{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>...
..>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...
>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>
>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>.
...<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..
>>.....>>>>><<.<<<<<<<<<<<..<<<<<<<.>>>>>>>.......
>>>>>..>>>>>>.>>............<<<<<<<<<..<<<........
.>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..
<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..
>>>>><<<<<<.......>>>>>>........<...........<<<<<.
......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>
>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..
{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<.<<
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<.....>>>>>>>>>>>..>>...>>>>......................
.................>>>.>>>>>>...<<<<<.....<<<<..<<.<
<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>
>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<...
..>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<
<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..
<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((
..(((..>>>>>>.)))))))))..........]]]]..}}]]]].....
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....<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<..
.......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>
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................>>>>>.><<<<....<<<<....<<.<<<<<<.}
}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<........
...>>>>>...>>>>>.>>>.....>>>>>>.....<<<<<<<.....<<
<.....<<.........<<<<<..<.<<....<<<<<.<<<<<..>>>.>
>...>>>>>..>>>.>>>>>........>>....<<..<<<<....<<<<
.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............
..>>>....>>>>>>><<<<<.<.............>....<<.<<<<<<
<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....
>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zvk The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
• Resolution: 3.49 Å
• Binding residue (original residue number in PDB): P2 R4 R6 K7 R9 R12 G13 H14 V15 H17 G18 H19 G20 R21 I22 G23 K24 H25 R26 K27 H28 G30 G31 R32 N34 G36 H39 H40 H41 R42 I43 N44 Y52 F53 G54 K55 G57 M58 R59 H60 Y61 H62 L63 K64 R65 N66 T72 N74 L81 S83 Q85 T86 N93 K94 D102 K110 L112 G113 K114 K116 S130 R131 R132 K136
• Binding residue (residue number reindexed from 1): P1 R3 R5 K6 R8 R11 G12 H13 V14 H16 G17 H18 G19 R20 I21 G22 K23 H24 R25 K26 H27 G29 G30 R31 N33 G35 H38 H39 H40 R41 I42 N43 Y51 F52 G53 K54 G56 M57 R58 H59 Y60 H61 L62 K63 R64 N65 T71 N73 L80 S82 Q84 T85 N92 K93 D101 K109 L111 G112 K113 K115 S129 R130 R131 K135

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zvk, PDBe:6zvk, PDBj:6zvk
• PDBsum: 6zvk
• PubMed: 33296660
• UniProt: G1SNY0|RL27A_RABIT Large ribosomal subunit protein uL15 (Gene Name=RPL27A)