Structure of PDB 8jsh Chain q Binding Site BS01

Receptor Information

>8jsh Chain q (length=117) Species: 562 (Escherichia coli)

RKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFA
AQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITD
VTPIPHNGCRPPKKRRV

Ligand information

>8jsh Chain g (length=1074)

aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaa
cacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacga
guggcggacgggugaguaaugucugggaaacugccugauggagggggaua
acuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagg
gggaccuucgggccucuugccaucggaugugcccagaugggauuagcuag
uaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagag
gaugaccagccacacuggaacugagacacgguccagacuccuacgggagg
cagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugcc
gcguguaugaagaaggccuucggguuguaaaguacuuucagcggggagga
agggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagc
accggcuaacuccgugccagcagccgcgguaauacggagggugcaagcgu
uaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucag
augugaaauccccgggcucaaccugggaacugcaucugauacuggcaagc
uugagucucguagagggggguagaauuccagguguagcggugaaaugcgu
agagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacu
gacgcucaggugcgaaagcguggggagcaaacaggauuagauacccuggu
aguccacgccguaaacgaugucgacuuggagguugugcccuugaggcgug
gcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaa
gguuaaaacucaaaugaauugccuuguacacaccgcccgucacaccaugg
gaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuac
cacuuugugauucaugacuggggugaagucguaacaagguaaccguaggg
gaaccugcgguuggaucaccuccu

.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....
<<<.<<<..<<<..<<.<......<................>.....>..
>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....
.<.<<........>>.>......>>.>.....<<<....>>>....<<<<
<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..
<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>
>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>.
..>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>
>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<.....
...<<<.<<<<.......>>>>.>>>..........>>>>>....>>.<<
<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>
>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<
<<<.......<<<<<<.....>>>>>>.....>>>>>>..>>>>>>>>>>
...<<<<<<<<...<<<<<<<....<<<<<<.....<<<......>>>..
......>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>
...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>..
.>>>>>>>>..........<<<<<<.<<<<<<<....<<.....>>....
>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....
>>>>....>>>..)))).]<.........>.......<<...<<<<...<
.......<..........<<<<<<.<<<<..<<....>>.>>>>>>>>>>
........>........>...>>>>....>>..........<<<<.<<<.
...>>>.>>>>.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8jsh Initiation factor 3 bound to the 30S ribosomal subunit in an initial step of translation.
• Resolution: 4.4 Å
• Binding residue (original residue number in PDB): H21 H23 S25 N27 N28 R36 Q37 G38 A40 T45 R52 G53 S54 K56 P114 I115 P116 H117 N118 C120 R121 P122 P123 K124 K125 R126 R127 V128
• Binding residue (residue number reindexed from 1): H10 H12 S14 N16 N17 R25 Q26 G27 A29 T34 R41 G42 S43 K45 P103 I104 P105 H106 N107 C109 R110 P111 P112 K113 K114 R115 R116 V117

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0070181 small ribosomal subunit rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8jsh, PDBe:8jsh, PDBj:8jsh
• PDBsum: 8jsh
• PubMed: 38148682
• UniProt: P0A7R9|RS11_ECOLI Small ribosomal subunit protein uS11 (Gene Name=rpsK)