Structure of PDB 8cgn Chain q Binding Site BS01

Receptor Information
>8cgn Chain q (length=127) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQVFGVARIYASFNDTFVHVTDLSGKETIARVTGGMKVKADRDESSPYAA
MLAAQDVAAKCKEVGITAVHVKIRATGGTRTKTPGPGGQAALRALARSGL
RIGRIEDVTPVPSDSTRKKGGRRGRRL
Ligand information
>8cgn Chain c (length=1624) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauacagugaaacugcgaauggcucauuaa
aucaguuaucguuuauuugauaguucccuacaugguauaacugugguaau
ucuagagcuaauacaugcuuaaaaucucagauguauuuauuagauaauga
ugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguuc
auucaaauuucugcccuaucaacuuucgaugguaggauaguggccuacca
ugguuucaacggguaacggggaauaaggguucgauuccggagagggagcc
ugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuaccc
aauccuaauucagggagguagugacaauaaauaacgauacauguaauugg
aaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucu
ggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguug
uugcaguuaaaaagcucguaguugaacuuugggcccgguugcaacggggc
cuuucuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcuc
gaauauauuagcauggaauaauagaauaggacguuugguucuauaggacc
aucguaaugauuaauagggacggucgggggcaucaguauucaauugucag
aggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugc
caaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugau
cagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggu
gguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuu
ggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacg
gaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgg
ggaaacucaccagguccagacacaauaaggauugacagauugagagcucu
uucuugauuuugugggugguggugcauggccguucuuaguugguggagug
auuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauag
uggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuuc
aagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacgu
ucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuugg
ccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagc
auuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucauc
agcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuag
uaccgauugaauggcuuagugaggccucaggaucugcuagcggagaauuu
ggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccgu
aggugaaccugcggaaggaucauu
...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<......>>...>>.>>......<<......
..<<<..<<..<<....<<<............<<......<<.<<.....
..>>.>>......>>........<<<<.>>>><...<<<<<<........
.......>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>
>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>
>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.
.........>>>.>>.<.<<....>>.>...>>>>>>.........<<<.
...<<<.....>>>..>>>..>....>.>.....<<<<<<..>>>.>>>.
.....<<..<...........>..>>.........<<<<<((....<.<<
<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>......
...<<<((.....<.<<...<<<.<<....<<<<<<.<<<..>>>.>>>>
>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>.
...>>......>>.>>..>>>.........<<<..<<<<<<<..>>>>>>
>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<
<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>
>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<
.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<
<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..))>>...>>....
.>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<
.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.
.........<<<<<.<....<<<<<........<<.<<<........>>>
.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<...
.>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<
<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<...
..>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.
>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<
<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<
<..........>>>>>>....>.....>>>>>>....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<
<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<..>>>>>...>..
>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<
<<<<..>>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cgn mRNA reading frame maintenance during eukaryotic ribosome translocation
Resolution2.28 Å
Binding residue
(original residue number in PDB)		N24 D25 F27 H29 G35 T38 R41 T43 G45 M46 D51 R52 E54 R84 G88 R90 V121 P122 S123 D124 S125 T126 R127 K129 G130 G131 R132 R133 R135 R136 L137
Binding residue
(residue number reindexed from 1)		N14 D15 F17 H19 G25 T28 R31 T33 G35 M36 D41 R42 E44 R74 G78 R80 V111 P112 S113 D114 S115 T116 R117 K119 G120 G121 R122 R123 R125 R126 L127
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8cgn, PDBe:8cgn, PDBj:8cgn
PDBsum8cgn
PubMed38030725
UniProtP06367|RS14A_YEAST Small ribosomal subunit protein uS11A (Gene Name=RPS14A)

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