Structure of PDB 7yly Chain q Binding Site BS01

Receptor Information
>7yly Chain q (length=541) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGR
NKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTN
LVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEIT
DKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPY
FNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFT
CPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVA
GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEE
LGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAI
DDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQ
FAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTDHLYKGVDIDGESDEG
VKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKK
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7yly Chain q Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yly Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		M46 D98 G99 N101 S169 A423 I517
Binding residue
(residue number reindexed from 1)		M45 D97 G98 N100 S168 A422 I509
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0051086 chaperone mediated protein folding independent of cofactor
Cellular Component
GO:0005737 cytoplasm
GO:0005832 chaperonin-containing T-complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yly, PDBe:7yly, PDBj:7yly
PDBsum7yly
PubMed36921056
UniProtP47079|TCPQ_YEAST T-complex protein 1 subunit theta (Gene Name=CCT8)

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