Structure of PDB 7qp6 Chain q Binding Site BS01

Receptor Information
>7qp6 Chain q (length=88) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWI
NTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGEL
Ligand information
>7qp6 Chain 7 (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB7qp6 Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.
Resolution4.7 Å
Binding residue
(original residue number in PDB)		K67 W70
Binding residue
(residue number reindexed from 1)		K46 W49
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, RNA binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0042255 ribosome assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

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Cellular Component
External links
PDB RCSB:7qp6, PDBe:7qp6, PDBj:7qp6
PDBsum7qp6
PubMed35489072
UniProtP47813|IF1AX_HUMAN Eukaryotic translation initiation factor 1A, X-chromosomal (Gene Name=EIF1AX)

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