Structure of PDB 7qh6 Chain q Binding Site BS01

Receptor Information

>7qh6 Chain q (length=128) Species: 9606 (Homo sapiens)

YRARPPPRRRPGPRWPDPEDLLTPRWQLGPRYAAKQFARYGAASGVVPGS
LWPSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAEC
MAKMPQMIVNWQQQQRENWEKAQADKER

Ligand information

>7qh6 Chain A (length=1133)

gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaagauu
uauagguagaggcgacaaaccuaccgagccuggugauagcugguugucca
agauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccu
uguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagga
aaaaaccuuguagagagaguaaaaaauuaucccaaacauauaacugaacu
ccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguua
guauaaguaacaugaaaacauucuccuccgcauaagccugcgucagacug
acaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccu
cacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagua
aaaggaaaaucuuaccuguuuaccaaaaacaucaccucuagcaucaccag
uauuagaggcaccgcccagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugg
agcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuaauaggguuuacgguucagaccgga
guaauccaggucgguuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>..>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..........>>
>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<
<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>....
.>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>.<.<<<.
.....>>>.>..<<<.<<<...<.....................>...>>
>>>>........>>>>>>...<<<<<......>>>>>.........>>>>
>><......<<..<<<....>>><<<<..<<<<........<<<<<.>>>
>>......<<<...<<<<.......................>>>>.....
..>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<
<.<<.............<<.........>>....<<<<<<..........
...>>>>>>..............>>.>>>>>>>>>>>>.>>.....>...
..<<<<<........>>>>>.......<<..<<<.........<<<<.<<
<<<<..<<<<..<<<<<<<<......>>>>>>>>.>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>.........<<<....>>>............>>>>
..>>>>>>........<<..<<<<<...>>>>..>.>>.....<<<<<<<
....>>>.>>>>.....>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>.......<<...........
.....>>..........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh6 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 3.08 Å
• Binding residue (original residue number in PDB): W50 K59 W143
• Binding residue (residue number reindexed from 1): W26 K35 W119

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qh6, PDBe:7qh6, PDBj:7qh6
• PDBsum: 7qh6
• PubMed: 35177605
• UniProt: Q8TAE8|G45IP_HUMAN Large ribosomal subunit protein mL64 (Gene Name=GADD45GIP1)