Structure of PDB 7of7 Chain q Binding Site BS01

Receptor Information

>7of7 Chain q (length=128) Species: 9606 (Homo sapiens)

YRARPPPRRRPGPRWPDPEDLLTPRWQLGPRYAAKQFARYGAASGVVPGS
LWPSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAEC
MAKMPQMIVNWQQQQRENWEKAQADKER

Ligand information

>7of7 Chain A (length=1376)

gcuaaaccuagccccaaaccccaccuuacuaccaaaccuuagccaaacca
uuuacauaaaguauaggcgauagaaauugauggcgcaauagauauaguac
cgcaagggaaagaaagcauaauauagcaaggacuaaccccuauaccuucu
gcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaaga
cccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgu
cuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuac
cgagccuggugauagcugguuguccaagaugaaucuuaguucaacuuuaa
auuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaa
gaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaa
aauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcgu
ucaagcucaacacaaaaaucccaaacauauaacugaacuccucacaccca
auuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaac
augaaaacauucuccuccgcauaagccugcgucagcugacaauuaacagc
ccaauaucuacaaucaaccaacaagucuuauuacccucacugucaaccca
acacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggc
aaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccagu
auuagaggcaccgccuuccuuaaauagggauggcuccacgaggguucagc
ugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggc
auaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugca
aacaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaa
ccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccuuugau
ccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauc
cuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggau
caggacaucccgauggugcagccgcuauuaaagguucguuuguucaacga
uuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuu
cuaucuacuuuaauuccucccuguacgaaaggacaagagaaauaaggccu
acuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauu
auacccacacacccaagaacaggguu

<<<.......<<<<..............................<.....
.>...........<<.....>>.........>>.>>.............<
<....>>.......>>>...........<<<.......>>>...<.<...
.....>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>.
..<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<<.
<<<<........>>>>>>>>....>>>.>>>>>...<<.......>>...
...>.>>>>......>.>>..<<<<<<...<<<<....>>>><<<.<<<<
<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<
<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<.
.............<....<<<.........>>>....>.......<<<..
....>>>..........................>...>>>>>>.......
.>>>>>>...<<<<<......>>>>>.........>>>>>>.......<<
..<<<....>>><<<<..<<<<........<<<<..>>>>......<<<.
..<<<<......................>>>>.......>>>.....<<.
.....>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........
<......<<<<<<..<<<.........>>>...<<<<<<...........
..>>>>>>....<<<.<<<<.....>>>>..>>>....>>.>>>>.....
>..>>.>>>>>>>>>>>>.>>...........<<<<<........>>>>>
.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<
......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.....
.<<<....>>>............>>>>..>>>>>>.......<<<...<<
<<<<<...<<.......>>...>>>>>>>....>>.>......<<<<<<.
<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>
.....>>>>>..>...>>>.>>>...<<<<<<<....>>>.>>>>....>
>..>>>.>>...<<<.<<<.................>>>.>>><<<<<..
.<<<....>>>.>>>>>......<<<.<............>.>>>.....
..........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of7 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): W50 R55 K59
• Binding residue (residue number reindexed from 1): W26 R31 K35

Gene Ontology

Molecular Function

• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of7, PDBe:7of7, PDBj:7of7
• PDBsum: 7of7
• PubMed: 34135319
• UniProt: Q8TAE8|G45IP_HUMAN Large ribosomal subunit protein mL64 (Gene Name=GADD45GIP1)