Structure of PDB 6x6t Chain q Binding Site BS01

Receptor Information

>6x6t Chain q (length=38) Species: 562 (Escherichia coli)

MKVRASVKKLCRNCKIVKRDGVIRVICSAEPKHKQRQG

Ligand information

>6x6t Chain a (length=2880)

gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgau
gaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguu
auaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuau
cauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacau
cuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcg
agcgaacggggagcagcccagagccugaaucaguguguguguuaguggaa
gcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaug
cacaugcugugagcucgaugaguagggcgggacacgugguauccugucug
aauauggggggaccauccuccaaggcuaaauacuccugacugaccgauag
ugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagug
aaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggc
gugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguag
caagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggc
guuaaguugcaggguauagacccgaaacccggugaucuagccaugggcag
guugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaa
uuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagau
agcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuc
cggggguagagcacuguuucggcaagggggucaacccgacuuaccaaccc
gaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgg
ggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggu
cccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcca
ggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucac
uggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccg
aagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucugua
agccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaa
ugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaaga
ccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaa
ggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguac
uugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgac
gguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaa
aucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaau
gcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguac
cccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaa
cucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggca
cgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaa
gauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaaca
cgaaaguggacguauacggugugacgccucccggugccggaagguuaauu
gaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcg
gccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccga
cugcacgaauggcguaaugauggccaggcugucuccacccgagacucagu
gaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaaga
ccccguaaccuuacuauagcuugacacugaacauugagccuugaugugua
ggauaggugggaggcuuugaaguguggacgccagucugcauggagccgac
cuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauc
cggguugcggacagugucugguggguaguuugacugggcggucuccuccu
aaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucag
gagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcg
agcaggugcgaaagcaggucauagugauccggugguucugaauggaaggg
ccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgccc
aagaguucauaucgacggcgguguuuggcacucggucggcucaucacauc
cuggggcugaaguaggucccaaggguauggcguucgccauuuaaaguggu
acgcgagcggguuuagaacgucgugagacagucggucccuaucugccgug
ggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggagug
gacgcaucacugguguucggguugucaugccaauggcacugcccgguagc
uaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccc
cgagaugaguucucccugacccuuuaaggguccugaaggaacguugaaga
cgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaa
ccgguacuaaugaaccgugaggcuuaaccu

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<...
...<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>...
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>
>......>>>>>.>.........<<....>>..<<<<<<.....<<....
.>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...
<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>
>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>.
.....<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>.....
..........<<....>>....>>.........<<<<.....>>>>....
..............>>>>>>>>>>>.......<<<<..<<<<<<....>>
>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<
<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>
.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<
<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>
>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>....
..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<
<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>
>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<
<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<
(((.....<<<<<<...........<<..<<<<<..<<........<<<<
<.<<...<<<<.......>>>>...>>........<<<......>>>..>
>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>.
..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<..
.<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.......
.>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<
<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...
<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))
<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....
[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>
>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...
>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>
>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....
<<<<<<<<.<<.........<.....<<<<<...............>>>>
><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>....
........<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<
<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<
...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..
<<<<......>>>>.........<..........<<<<<<.....>>>>>
>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>
.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<.....
.<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<......
.....<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>...
.........>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....
>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<.
..........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>
>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>.
.>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>
>>>>>>..............>>>....>>>........<<...<<<<<<.
..<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<
<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>
..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>
>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>
>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>
>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>
>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<....
...>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...
>>>>>.>>>.....>>..>..>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6x6t Structural basis of transcription-translation coupling.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): M1 K2 V3 R4 A5 S6 V7 K8 L10 K15 V17 R19 R24 P31 K32 K34 R36 Q37 G38
• Binding residue (residue number reindexed from 1): M1 K2 V3 R4 A5 S6 V7 K8 L10 K15 V17 R19 R24 P31 K32 K34 R36 Q37 G38

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6x6t, PDBe:6x6t, PDBj:6x6t
• PDBsum: 6x6t
• PubMed: 32820061
• UniProt: P0A7Q6|RL36_ECOLI Large ribosomal subunit protein bL36A (Gene Name=rpmJ)