Structure of PDB 6i9r Chain q Binding Site BS01

Receptor Information
>6i9r Chain q (length=130) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YRARPPPRRRPGPRWPDPEDLLTPRWQLGPRYAAKQFARYGAASGVVPGS
LWPSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAEC
MAKMPQMIVNWQQQQRENWEKAQADKERRA
Ligand information
>6i9r Chain A (length=1501) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagcc
aaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgc
aauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaa
uauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaa
uaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcua
ccuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggga
agauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguu
guccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuaa
auccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggac
acuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguag
gccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauaacacaacugacaauuaacagcccaauaucu
acaaucaaccaacaagucauuauuacccucacugucaacccaacacaggc
augcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuua
ccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagagg
caccgccugcccagugacacauguuuaacggccgcgguacccuaaccgug
caaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggc
uccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugc
ccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcu
uuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguu
ggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacu
ucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagc
cgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugag
uucagaccggaguaauccaggucgguuucuaucuacuuauuccucccugu
acgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgu
aaaugauaucaucucaacuuaguauacccacacccacccaagaacagggu
u
<<.......<<<<.....................................
<......>.........<.....<<.....>>....>........>>.>>
.............<<....>>......................>>.....
.......<<<.......>>>...<.<........>.>.<<<<<<......
...<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<
<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>.
...>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..
<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......
.>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>
...<<<......>>>....<<<.<<<...<..............<....<
<<.........>>>....>.......<<<......>>>............
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>><......<<..<<<....>>><<<<..
<<<<........<<<<<.........>>>>>......<<<...<<<<...
....................>>>>.......>>>.....<<......>>.
>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<
<<<<<..<<<.........>>>...<<<<<<.............>>>>>>
....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>
........<...........<<<<<<.....>>>>>>.....>....>>>
....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<
<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<
..<<<<..<<<<<<<<...............>>>>>>>>.>>>>..<<<<
.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<
.....>>>>..>>>....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...
>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<.....
.>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>
....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.....
............>>>.>>><<<<<...<<<....>>>.>>>>>......<
<<................>>>..............<<<<.......>>>>
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6i9r Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R34 R38 R49 W50 R55
Binding residue
(residue number reindexed from 1)		R10 R14 R25 W26 R31
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6i9r, PDBe:6i9r, PDBj:6i9r
PDBsum6i9r
PubMed33910005
UniProtQ8TAE8|G45IP_HUMAN Large ribosomal subunit protein mL64 (Gene Name=GADD45GIP1)

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