Structure of PDB 5k0y Chain q Binding Site BS01

Receptor Information
>5k0y Chain q (length=237) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSL
Ligand information
>5k0y Chain A (length=1776) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagcggcggcg
gcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcgg
cgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccg
ugccuaccauggugaccacgggugacggggaaucaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccacucccgacccggggagguagugacgaaaaauaacaauaca
ggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuua
acgaggauccauuggagggcaagucuggucgcagcagccgcgguaauucc
agcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguug
gaucuugagggcccgccccucggcgcccccucgaugugucccgcggggcc
cgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccg
ccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuug
uugguuuucggaacugaggccaugauuaagagggacggccgggggcauuc
guauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccag
agcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgg
agguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugcc
gacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgg
gaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaac
uuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaa
uuugacucaacacgggaaaccucacccggcccggacacggacaggauuga
cagauugauagcucuuucucgauucugugggugguggugcauggccguuc
uuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacuc
uggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggc
ucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccc
cauucgugauggggaucggggauugcaauuauuccccaugaacgaggaau
ucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuu
guacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccuc
ggaucggcccgccggggucggcccacggcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccg
uaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[....................<<.....
<<.<<<.....>>>.>>......>>..........<<...<<.<......
>.>>...>>..[[..(((((.....<<<<<<<<<<<<.<........>>>
>..............)))))......]]...<<<<.<<<......>>>.>
>>>....]]]...}}....]]].<<<....<<<....<<<<<<<......
...>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}
}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]]....
.....<<<....<<<.....>>>..>>>......}}.......<<<<<<<
<<.<<<....>>>.>>.>>>>.>>>......<<..<...........>..
>>.........<<<<<((......<<<<.....<<..))>>.......>>
>>.>>>>>..)))))).]]]............{{.......{{...[[[.
[[......<<.>>...........<<<<<...............>>>>>.
........<<<<<..<.......<<...<.......>.<<<<.......>
>>>...>>......>..>>..>>>.......[[....(((((((.....>
>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<
<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>......
.<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<
<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<
..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>
>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<....
..<<........>>..........<<<<<......<<<<<<.......<<
.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<<<<<<<<.
...<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<
...<...<<<<..<<<<....<<<..<<<<....>>>>.>>>....>>>>
..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>
>...>.>>>>>>>>.....>>>>>...>>.>>>>.>>>.....<<.<<<.
.......<.......<<<.<<<<....>>>>.>>>....>.........>
>>.>>............<<<<<..........>>>>>...........>>
>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>
>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<
...<<<<<.<<<<<<<<...........>>>>>>>.>...>>>>>...>>
.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<
<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5k0y eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Resolution5.8 Å
Binding residue
(original residue number in PDB)		N4 P8 G11 Q13 L15 A33 S53 G55 N56 Q59 G60 P62 Q65 G66 L68 R72 R74 S82 C83 Y84 R85 R87 R88 T89 G90 R92 K93 R94 K95 S96 S107 V108 N110 K115 R131 R132 L133 G134 K136 R137 S139 R140 R142 K143 K149 E150 V153 R154 Q155 V157 R159 L162 E165 G166 K167 K168 P169 R170 T171 K172 A173 P174 K175 I176 Q177 R178 V180 T181 R183 Q186 H187 K188 R189 R190 R191 I192 K195 K196 R198 T199 N202 R224 E226 I228 K230 R231 R232 R233 S235 L237
Binding residue
(residue number reindexed from 1)		N4 P8 G11 Q13 L15 A33 S53 G55 N56 Q59 G60 P62 Q65 G66 L68 R72 R74 S82 C83 Y84 R85 R87 R88 T89 G90 R92 K93 R94 K95 S96 S107 V108 N110 K115 R131 R132 L133 G134 K136 R137 S139 R140 R142 K143 K149 E150 V153 R154 Q155 V157 R159 L162 E165 G166 K167 K168 P169 R170 T171 K172 A173 P174 K175 I176 Q177 R178 V180 T181 R183 Q186 H187 K188 R189 R190 R191 I192 K195 K196 R198 T199 N202 R224 E226 I228 K230 R231 R232 R233 S235 L237
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019901 protein kinase binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001890 placenta development
GO:0002181 cytoplasmic translation
GO:0002309 T cell proliferation involved in immune response
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006924 activation-induced cell death of T cells
GO:0007369 gastrulation
GO:0008284 positive regulation of cell population proliferation
GO:0022605 mammalian oogenesis stage
GO:0031929 TOR signaling
GO:0033077 T cell differentiation in thymus
GO:0042274 ribosomal small subunit biogenesis
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0048821 erythrocyte development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030425 dendrite
GO:0032040 small-subunit processome
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0044297 cell body
GO:0048471 perinuclear region of cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5k0y, PDBe:5k0y, PDBj:5k0y
PDBsum5k0y
PubMed27373335
UniProtG1TM55|RS6_RABIT Small ribosomal subunit protein eS6 (Gene Name=RPS6)

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