Structure of PDB 8wav Chain p Binding Site BS01

Receptor Information
>8wav Chain p (length=1146) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPI
DLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARL
RNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNG
LTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKY
AYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQ
EVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQN
VALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFL
GYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEV
RIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAG
VSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETP
EGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADAT
KIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIY
TDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYI
DTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPD
HNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSME
YLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK
EQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDV
IIGKTVTLPTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRI
PQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTI
GHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVL
YNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGR
SRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIA
NTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Ligand information
>8wav Chain Y (length=54) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tccgtaggcacgtctgctcggctcgaagtccatgaagttgatgaagaaga
actc
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wav Structural Visualization of de novo Transcription Initiation.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		R438 T450 L747 R812 G1077 R1078 R1085 M1089
Binding residue
(residue number reindexed from 1)		R423 T435 L732 R797 G1049 R1050 R1057 M1061
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wav, PDBe:8wav, PDBj:8wav
PDBsum8wav
PubMed38127763
UniProtI3LGP4

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