Structure of PDB 8s8e Chain p Binding Site BS01

Receptor Information
>8s8e Chain p (length=544) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QEDFFTRLQTIIDSRGKKTVNQQSLISTLEELLTVAEKPYEFIMAYLTLI
PSRFDASANLSYQPIDQWKSSFNDISKLLSILDQTIDTYQVNEFADPIDF
IEDEPKEDSDGVKRILGSIFSFVERLDDEFMKSLLNIDPHSSDYLIRLRD
EQSIYNLILRTQLYFEATLKDEHDLERALTRPFVKRLDHIYYKSENLIKI
METAAWNIIPAQFKSKFTSKDQLDSADYVDNLIDGLSTILSKQNNIAVQK
RAILYNIYYTALNKDFQTAKDMLLTSQVQTNINQFDSSLQILFNRVVVQL
GLSAFKLCLIEECHQILNDLLSSSHLREILGQQSLHRISLNSSNNASADE
RARQCLPYHQHINLDLIDVVFLTCSLLIEIPRMTAFYSGIKVKRIPYSPK
SIRRSLEHYDKLSFQGPPETLRDYVLFAAKSMQKGNWRDSVKYLREIKSW
ALLPNMETVLNSLTERVQVESLKTYFFSFKRFYSSFSVAKLAELFDLPEN
KVVEVLQSVIAELEIPAKLNDEKTIFVVEKGDEITKLEEAMVKL
Ligand information
>8s8e Chain 2 (length=1798) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucug
ugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagag
auguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauuca
uaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaa
uuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuc
aacggguaacggggaauaaggguucgauuccggagagggagccugagaaa
cggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccua
auucagggagguagugacaauaaauaacgauacagggcccauucgggucu
uguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggag
ggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguaua
uuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguug
uccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuuc
uggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuu
gaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcaug
gaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccau
cguaaugauuaauagggacggucgggggcaucaguauucaauugucagag
gugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugcca
aggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugauca
gauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugg
uguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuugg
guucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggg
aaacucaccagguccagacacaauaaggauugacagauugagagcucuuu
cuugauuuugugggugguggugcauggccguucuuaguugguggagugau
uugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggg
uugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaag
ccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucu
gggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccg
agaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauu
guaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagc
uugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguac
cgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaa
cuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacu
aaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<..........<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<................<<.....<<.
<<<.....>>>.>>......>>........<<<<<..<<....>>..>>>
>><...<<<<<<......(((((((.<<<....>>>..............
>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>
>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>...
...>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<........
..>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.
....>>>..>>>.......>.>.....<<<<<<<<<.<.......>..>>
>>>>.>>>......<<..<...........>..>>.........<<<<<(
(......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>
>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<
..<<<<.<<<.......>>>...>>>>.....>>>>>>>>>>>......<
<<<....<.<<<<<<.......>>>>>>.>....>>>.>....<<<<<.<
<.......<<...<.......>..<<<....>>>....>>......>>.>
>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.
>>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<
......>>>......>.>>>>>>.>>>.......<<....>>...>>>>.
.>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<
.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>
>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<
<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>...
.......<<<<<.<....<<<<<........<<.<<<........>>>.>
>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......
>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<
<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>
>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>
>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<.
...>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..
........>>>>>>....>.....>>>>>>....<<<<<<<<.......>
>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<
<....<<<<<<<<.<<<..<<<<..<...<<<<<<..<............
.......>...>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>
>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8s8e Structural basis of AUC codon discrimination during translation initiation in yeast.
Resolution3.85 Å
Binding residue
(original residue number in PDB)
N309 S311 N595 D599
Binding residue
(residue number reindexed from 1)
N59 S61 N345 D349
External links
PDB RCSB:8s8e, PDBe:8s8e, PDBj:8s8e
PDBsum8s8e
PubMed39193907
UniProtP32497|EIF3C_YEAST Eukaryotic translation initiation factor 3 subunit C (Gene Name=NIP1)

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