Structure of PDB 8i0p Chain p Binding Site BS01

Receptor Information
>8i0p Chain p (length=169) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQA
FVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMPNYILFLN
NLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDA
LQGFKITPSHAMKITYAKK
Ligand information
>8i0p Chain H (length=165) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucag
uuuaauaucugauguccucucgaggacggauuuuuggagcagggagaugg
aauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguac
cuccaggaacggugc
..............................................<<<<
........>>>>..<<<<<..>>>>>................<<<..<<<
<...<<<<....>>>>.>>>>.>>>..<<<<<<.<<<<<...........
..>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB8i0p Molecular Basis for the activation of Human spliceosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D16 K19 A42 K44 K47 R49 G50
Binding residue
(residue number reindexed from 1)		D14 K17 A40 K42 K45 R47 G48
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005685 U1 snRNP
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtP08579|RU2B_HUMAN U2 small nuclear ribonucleoprotein B'' (Gene Name=SNRPB2)

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