Structure of PDB 7w5b Chain p Binding Site BS01

Receptor Information
>7w5b Chain p (length=94) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQA
FVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRG
Ligand information
>7w5b Chain H (length=140) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuua
auaucguccucuaccgaggacaauauuaaggauuuuuggagcagggagcc
acgcaucgaccugguauugcaguaccuccaggaacggugc
...............................................<<<
<<<..<<<<<<....>>>>>>..>>>>>>...............<.....
.><<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB7w5b Mechanism of exon ligation by human spliceosome.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		Y10 N12 N13 D16 K17 K19 K20 K24 V41 A42 L43 K44 T45 M46 K47 M48 R49 Q51 F53 K77 Q82 A84 K85 T86 D87 S88 D89
Binding residue
(residue number reindexed from 1)		Y8 N10 N11 D14 K15 K17 K18 K22 V39 A40 L41 K42 T43 M44 K45 M46 R47 Q49 F51 K75 Q80 A82 K83 T84 D85 S86 D87
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005685 U1 snRNP
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5b, PDBe:7w5b, PDBj:7w5b
PDBsum7w5b
PubMed35705093
UniProtP08579|RU2B_HUMAN U2 small nuclear ribonucleoprotein B'' (Gene Name=SNRPB2)

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