Structure of PDB 7oqe Chain p Binding Site BS01

Receptor Information
>7oqe Chain p (length=444) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELEPFQKNFYIESETVSSMSEMEVEELRLSLDNIKIKGTGCPKPVTKWSQ
LGLSTDTMVLITKLHFGSLTPIQSQALPAIMSGRDVIGISKTGSGKTISY
LLPLLRQVKAQRPLSKHETGPMGLILAPTRELALQIHEEVTKFTEADTSI
RSVCCTGGSEMKKQITDLKRGTEIVVATPGRFIDILTLNDGKLLSTKRIT
FVVMDEADRLFDLGFEPQITQIMKTVRPDKQCVLFSATFPNKLRSFAVRV
LHSPISITINSKGMVNENVKQKFRICHSEDEKFDNLVQLIHERSEFFDAK
AIIFVSSQNICDFISKKLLNAGIVTCAIHAGKPYQERLMNLEKFKREKNS
ILLCTEVLSRGLNVPEVSLVIIYNAVKTFAQYVHTTGRTARGSRSGTAIT
LLLHDELSGAYILSKAMRDEEIKALDPLQAKELQEMSAKFESGM
Ligand information
>7oqe Chain 2 (length=143) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guguaguaucuguucuuuucaguguaacaacugaaaugaccucgaggcuc
auacacauuuuuuggcaggacgggaagaggagacgucgcgacccucgcag
agucguucuugacuuggucgcuugauguuucuucuucccguuc
.................<<<<<<......>>>>>><<<<<<<..>>>.>>
>>................<<<<<<<<<<.<<<<<<<<<<<<.<<.....<
<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB7oqe Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Resolution5.9 Å
Binding residue
(original residue number in PDB)		G368 M371 K372 K379
Binding residue
(residue number reindexed from 1)		G158 M161 K162 K169
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008186 ATP-dependent activity, acting on RNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000348 mRNA branch site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0022613 ribonucleoprotein complex biogenesis
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oqe, PDBe:7oqe, PDBj:7oqe
PDBsum7oqe
PubMed34349264
UniProtP21372|PRP5_YEAST Pre-mRNA-processing ATP-dependent RNA helicase PRP5 (Gene Name=PRP5)

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