Structure of PDB 6gsm Chain p Binding Site BS01

Receptor Information
>6gsm Chain p (length=651) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QYIVVNGAPVIPSAKVPVLKKALTSLFSKAGKVVNMEFPIDEATGKTKGF
LFVECGSMNDAKKIIKSFHGKRLDLKHRLFLYTMKDVERYNSDDFDTEFR
EPDMPTFVPSSSLKSWLMDDKVRDQFVLQDDVKTSVFWNSMFNEEDSLVE
SRENWSTNYVRFSPKGTYLFSYHQQGVTAWGGPNFDRLRRFYHPDVRNSS
VSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATF
PVIKSPYLKWPLVRWSYNDKYCARMVGDSLIVHDATKNFMPLEAKALKPS
GIRDFSFAPEGVKLQPFRNGDEPSVLLAYWTPETNNSACTATIAEVPRGR
VLKTVNLVQVSNVTLHWQNQAEFLCFNVERHTKSGKTQFSNLQICRLTER
DIPVEKVELKDSVFEFGWEPHGNRFVTISVHEVADMNYAIPANTIRFYAP
ETKEKTDVIKRWSLVKEIPKTFANTVSWSPAGRFVVVGALVGPNMRRSDL
QFYDMDYPGEKNINDNNDVSASLKDVAHPTYSAATNITWDPSGRYVTAWS
SSLKHKVEHGYKIFNIAGNLVKEDIIAGFKNFAWRPRPLSNAERKKVRKN
LREWSEEQDAMEADTAMRHQRELLKQWTEYREKIGQEMEKSMNFKIFDVQ
P
Ligand information
>6gsm Chain 2 (length=1798) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucug
ugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagag
auguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauuca
uaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaa
uuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuc
aacggguaacggggaauaaggguucgauuccggagagggagccugagaaa
cggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccua
auucagggagguagugacaauaaauaacgauacagggcccauucgggucu
uguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggag
ggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguaua
uuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguug
uccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuuc
uggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuu
gaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcaug
gaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccau
cguaaugauuaauagggacggucgggggcaucaguauucaauugucagag
gugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugcca
aggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugauca
gauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugg
uguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuugg
guucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggg
aaacucaccagguccagacacaauaaggauugacagauugagagcucuuu
cuugauuuugugggugguggugcauggccguucuuaguugguggagugau
uugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggg
uugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaag
ccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucu
gggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccg
agaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauu
guaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagc
uugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguac
cgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaa
cuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacu
aaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[...<....<<....<<..........>>...>>.>.......{{..
......[[[......{{....[[[{...............<<.....<<.
.<.......>..>>......>>........<<<<<............>>>
>>{..[[.((((......<<<<<<<<.<......>...............
))))]].....}...<<<<..<<<.....>>>.>>>>..}.]]]...}}.
...]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>...
...>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<........
..>>>.>>.<.<......>.>...]]]]]].........<<<....<<<.
....>>>..>>>................<..<<<<<.<.......>..>>
>>>...>.......<<..<...........>.>.>.........<<<<<(
(......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]
]]].........[[[{{.......{{...[[[.{{.....<<<<<<<<<<
.<<<<<.<<<.......>>>...>>>>>....>>>>>>>>>>.....<<<
<<<......<.................>......>>>>>>...<<<<<.<
<......<<<...<.......>..<<<....>>>....>>.>....>>.>
>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).
]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<.
.......>>......>.>>>>>>..>>.......<<....>>...>>>>.
..>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<....
.....>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<
.<<.<.......>>>>>>>>>>>..>>>...<<..}}>>...>>.....>
>>.]]].<<<......<.<......>.>....>>>..]]]]..<<<<<.<
<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>...
.......<<<<<.<....<<<<<........<<..<<........>>..>
>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......
>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<....<<
<<<.<<<<....>>>>.>.>>>>....>>>>.>>....<<<<<<.....>
>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>
>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<..<<<.
...>>>..>>>....>>.......>>>>>>>......<....<<<<<<..
........>>>>>>....>.....>>>>>>....<<<<<<<<.......>
>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<
<....<<<<<<<<.<<<..<<<<......<<<<<<.<<............
......>>...>>>>>>......>>>>..>>>.>>>>>>>>...>>.>>>
>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gsm Large-scale movement of eIF3 domains during translation initiation modulate start codon selection.
Resolution5.15 Å
Binding residue
(original residue number in PDB)		P88 K91 K122 K363 R394 N395 K531 T532
Binding residue
(residue number reindexed from 1)		P12 K15 K46 K287 R318 N319 K455 T456
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0031369 translation initiation factor binding
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005852 eukaryotic translation initiation factor 3 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gsm, PDBe:6gsm, PDBj:6gsm
PDBsum6gsm
PubMed34648019
UniProtP06103|EIF3B_YEAST Eukaryotic translation initiation factor 3 subunit B (Gene Name=PRT1)

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