Structure of PDB 7ls2 Chain o2 Binding Site BS01

Receptor Information
>7ls2 Chain o2 (length=214) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLK
RTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGR
FTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDS
PLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLY
FYRDPEEIEKEEQA
Ligand information
>7ls2 Chain m2 (length=1724) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugaccccccuucccggggggg
gaugcgugcauuuaucagauggugacucuagauaaccucgggccgaucgc
acgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuu
ucgaugguagucgccgugccuaccauggugaccacgggugacggggaauc
aggguucgauuccggagagggagccugagaaacggcuaccacauccaagg
aaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugac
gaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguc
cacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccag
cagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguu
aaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggcg
gggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccg
agccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucua
uuuuguugguuuucggaacugaggccaugauuaagagggacggccggggg
cauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacgg
accagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaa
gucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacg
augccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcu
uccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcu
gaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcgg
cuuaauuugacucaacacgggaaaccucacccggcccggacacggacagg
auugacagauugauagcucuuucucgauuccgugggugguggugcauggc
cguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacga
gacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccc
caacuucuuagagggacaaguggcguucagccacccgagauugagcaaua
acaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacug
acuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguu
gaaccccauucgugauggggaucggggauugcaauuauuccccaugaacg
aggaauucccaguaagugcgggucauaagcuugcguugauuaagucccug
cccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugag
gcccucggaucggccccgccggggugcccuggcggagcgcugagaagacg
gucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccgua
ggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<...<....<<....<<..........>>...>>.>.......<<...
.....<<<.<.<..<<....<<<<<.........<<..<...<..<....
...>..>......>>>.........<<<<...<<<<<<<....>>>>>>>
...>>>><<..<<<<<....<......>..>>>>>......>>...<<<<
.<<<<......>>>>>>>>.>>.>>>...>>>.>.>>>.<<<....<<<.
.....<<<<<.........>>>>>..>>>......>>>...<<<.<<<<.
...>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>
>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...
>>.>.....<<<<<<<<<.<<.......>>.>>>>>.>>>>......<<.
.<...........>..>>.........<<<<<((......<<<<.....<
<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((
.....<.<<...<<<.............<<<..>>>.....<..<.....
.......>.>...<<<<<<.<.......<<...<.......>..<<....
.....>.>...>>......>.>>>..>>>........<.<..<<<<<<<.
..............>>>>>>>..>.>..........<<<<<<..<...<<
<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.
......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....
<<<<<<....<...<<<<.........>>>>...>.>>>>>>........
..<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>
...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<
<......<<........>>..........<<<<<......<<<<<.....
...<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<
<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>..
..<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>....
.>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>
>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.>...<
<.<<<........<.......<<<<<<<<....>>>>>>>>....>....
.....>>>.>>............<<<<<..........>>>>>.......
....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>
>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...
<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>
>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<
<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ls2 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F32 R41 R102 P105 N110 Q132 Y139 R155 Y156
Binding residue
(residue number reindexed from 1)		F30 R39 R100 P103 N108 Q130 Y137 R153 Y154
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005055 laminin receptor activity
GO:0005515 protein binding
GO:0043236 laminin binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0007155 cell adhesion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ls2, PDBe:7ls2, PDBj:7ls2
PDBsum7ls2
PubMed34815424
UniProtP14206|RSSA_MOUSE Small ribosomal subunit protein uS2 (Gene Name=Rpsa)

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