Structure of PDB 9fmd Chain o Binding Site BS01

Receptor Information
>9fmd Chain o (length=162) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSD
NEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLV
ELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVK
LKERQEAEKMFK
Ligand information
>9fmd Chain 2 (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuauc
aguuuaauauauauuaaaagauuuuuggaacugcaucgaccugguauugc
aguaccuccaggaacggugc
..................................................
...<<<<<<..>>>>>>...............<<<<<<.<<<<<......
.......>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB9fmd Mechanism for the initiation of spliceosome disassembly.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		K151 L152
Binding residue
(residue number reindexed from 1)		K150 L151
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030620 U2 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0007283 spermatogenesis
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Cellular Component
External links
PDB RCSB:9fmd, PDBe:9fmd, PDBj:9fmd
PDBsum9fmd
PubMed38925148
UniProtP09661|RU2A_HUMAN U2 small nuclear ribonucleoprotein A' (Gene Name=SNRPA1)

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