Structure of PDB 7y7d Chain o Binding Site BS01

Receptor Information

>7y7d Chain o (length=114) Species: 562 (Escherichia coli)

SNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIR
NRGLHSAFTVRKISNGEGVERVFQTHSPVVDSISVKRRGAVRKAKLYYLR
ERTGKAARIKERLN

Ligand information

>7y7d Chain A (length=1520)

aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacg
aguggcggacgggugaguaaugucugggaaacugccugauggagggggau
aacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagag
ggggccucuugccaucggaugugcccagaugggauuagcuaguagguggg
guaacggcucaccuaggcgacgaucccuagcuggucugagaggaugacca
gccacacuggaacugagacacgguccagacuccuacgggaggcagcagug
gggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguau
gaagaaggccuucggguuguaaaguacuuucagcggggaggaagggagua
aaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcua
acuccgugccagcagccgcgguaauacggagggugcaagcguuaaucgga
auuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaa
uccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucu
cguagagggggguagaauuccagguguagcggugaaaugcguagagaucu
ggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcuca
ggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacg
ccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcua
acgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaa
augaauugacgggggcccgcacaagcgguggagcaugugguuuaauucga
ugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucaga
gaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucg
ucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaaccc
uuauccuuuguugccagcgguccggccgggaacucaaaggagacugccag
ugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuac
gaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccu
cgcgagagcaagcggaccucauaaagugcgucguaguccggauuggaguc
ugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaau
gccacggugaauacguucccgggccuuguacacaccgcccgucacaccau
gggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuu
accacuuugugauucaugacuggggugaagucguaacaagguaaccguag
gggaaccugcgguuggauca

........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>.
.>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<...
..<<<<<......>>>>>......>>.>.....<<<....>>>....<<<
<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.
........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>
.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<
......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<
<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((..
.<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>...
.......<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....
..<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<
<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>
>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>..
.>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>
>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..
))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..
)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<.
.......>>..........<<<<<<<......<<<<<<<..<<<<<<<..
..>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<....
...<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<
<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<
<.....>>>>>........>>>>.........>>>...>>>>>>>>>...
>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<
<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<
........>>>>>>>....>.....>>>>>>....<<<<<<<........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<
<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>
>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<
<....>>>>>>>>>......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y7d Glycosylation of queuosine in tRNAs contributes to optimal translation and post-embryonic growth in vertebrates (Under submission)
• Resolution: 2.58 Å
• Binding residue (original residue number in PDB): R39 Q41 G105 K106 R109 L114
• Binding residue (residue number reindexed from 1): R38 Q40 G104 K105 R108 L113

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7y7d, PDBe:7y7d, PDBj:7y7d
• PDBsum: 7y7d
• PubMed: 37992713
• UniProt: P0A7K6|RL19_ECOLI Large ribosomal subunit protein bL19 (Gene Name=rplS)