Structure of PDB 7unr Chain o Binding Site BS01

Receptor Information

>7unr Chain o (length=88) Species: 208964 (Pseudomonas aeruginosa PAO1)

ALSVEEKAQIVNEYKQAEGDTGSPEVQVALLSANINKLQDHFKANGKDHH
SRRGLIRMVNQRRKLLDYLKGKDVSRYTALIGRLGLRR

Ligand information

>7unr Chain a (length=1522)

gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggc
ggacgggugaguaaugccuaggaaucugccugguagugggggauaacguc
cggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggau
cuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggu
gggguaaaggccuaccaaggcgacgauccguaacuggucugagaggauga
ucagucacacuggaacugagacacgguccagacuccuacgggaggcagca
guggggaauauuggacaaugggcgaaagccugauccagccaugccgcgug
ugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggc
aguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccgg
cuaacuucgugccagcagccgcgguaauacgaagggugcaagcguuaauc
ggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugug
aaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagag
uacgguagagggugguggaauuuccuguguagcggugaaaugcguagaua
uaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacac
ugaggugcgaaagcguggggagcaaacaggauuagauacccugguagucc
acgccguaaacgaugucgacuagccguugggaucgaucuuaguggcgcag
cuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacu
caaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauu
cgaagcaacgcgaagaaccuuaccuggccuugacaugcugagaacuuucc
agagauggauuggugccuucgggaacucagacacaggugcugcauggcug
ucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaa
cccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugc
cggugacaaaccggaggaagguggggaugacgucaagucaucauggcccu
uacggccagggcuacacacgugcuacaauggucgguacaaaggguugcca
agccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgca
gucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucag
aaugucacggugaauacguucccgggccuuguacacaccgcccgucacac
caugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacg
guuaccacggagugauucaugacuggggugaagucguaacaagguagccg
uaggggaaccugcggcuggauc

........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>
......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<
<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<
<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<
<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>..
.>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>
>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<
<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<
<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<((
(...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>
..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.
.....<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<
<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>
>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>
>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<
<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>
>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......
<<........>>..........<<<<<<<......<<<<<<<......<<
<....>>>.......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.
......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....
.<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<
<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>
...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..
.<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<
<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.....
....>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<
<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>
>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<
<<<<....>>>>>>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7unr Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): A2 K8 D21 T22 G23 Q28 H42 N46 K48 D49 H51 S52 R54 R58 N61 K65 Y69
• Binding residue (residue number reindexed from 1): A1 K7 D20 T21 G22 Q27 H41 N45 K47 D48 H50 S51 R53 R57 N60 K64 Y68

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7unr, PDBe:7unr, PDBj:7unr
• PDBsum: 7unr
• UniProt: Q9HV58|RS15_PSEAE Small ribosomal subunit protein uS15 (Gene Name=rpsO)