Structure of PDB 7r6q Chain o Binding Site BS01

Receptor Information

>7r6q Chain o (length=133) Species: 1247190 (Saccharomyces cerevisiae BY4741)

EYSGIIYVSRLPHGFHEKELSKYFAQFGDLKEVRLARNKKTGNSRHYGFL
EFVNKEDAMIAQESMNNYLLMGHLLQVRVLPKGAKIEKLYKYKKRVLVEK
GITKPVKQLKDNMKQKHEERIKKLAKSGIEFKW

Ligand information

>7r6q Chain 6 (length=87)

ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacu
ugaaauugcuggccuuuaggcgaacaauguucuuaaa

......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>
>..........<<<<..>>>>................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7r6q Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
• Resolution: 2.98 Å
• Binding residue (original residue number in PDB): Y94 S96 R97 H100 K109 R124 N125 K126 N130 S131 R132 H133 Y134 F136 L156 M158 H160 K172 I173 E174 K175 Y177 Y179 R182 V183 V185 T190 K191 L196 R207
• Binding residue (residue number reindexed from 1): Y7 S9 R10 H13 K22 R37 N38 K39 N43 S44 R45 H46 Y47 F49 L69 M71 H73 K85 I86 E87 K88 Y90 Y92 R95 V96 V98 T103 K104 L109 R120

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0030687 preribosome, large subunit precursor
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7r6q, PDBe:7r6q, PDBj:7r6q
• PDBsum: 7r6q
• PubMed: 36482249
• UniProt: P53927|NOP15_YEAST Ribosome biogenesis protein 15 (Gene Name=NOP15)