Structure of PDB 7qh6 Chain o Binding Site BS01

Receptor Information

>7qh6 Chain o (length=91) Species: 9606 (Homo sapiens)

IPGRQWIGKHRRPRFVSLRAKQNMIRRLEIEAENHYWLSMPYMTREQERG
HAAVRRREAFEAIKAAATSKFPPHRFIADQLDHLNVTKKWS

Ligand information

>7qh6 Chain A (length=1133)

gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaagauu
uauagguagaggcgacaaaccuaccgagccuggugauagcugguugucca
agauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccu
uguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagga
aaaaaccuuguagagagaguaaaaaauuaucccaaacauauaacugaacu
ccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguua
guauaaguaacaugaaaacauucuccuccgcauaagccugcgucagacug
acaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccu
cacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagua
aaaggaaaaucuuaccuguuuaccaaaaacaucaccucuagcaucaccag
uauuagaggcaccgcccagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugg
agcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuaauaggguuuacgguucagaccgga
guaauccaggucgguuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>..>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..........>>
>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<
<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>....
.>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>.<.<<<.
.....>>>.>..<<<.<<<...<.....................>...>>
>>>>........>>>>>>...<<<<<......>>>>>.........>>>>
>><......<<..<<<....>>><<<<..<<<<........<<<<<.>>>
>>......<<<...<<<<.......................>>>>.....
..>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<
<.<<.............<<.........>>....<<<<<<..........
...>>>>>>..............>>.>>>>>>>>>>>>.>>.....>...
..<<<<<........>>>>>.......<<..<<<.........<<<<.<<
<<<<..<<<<..<<<<<<<<......>>>>>>>>.>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>.........<<<....>>>............>>>>
..>>>>>>........<<..<<<<<...>>>>..>.>>.....<<<<<<<
....>>>.>>>>.....>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>.......<<...........
.....>>..........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh6 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 3.08 Å
• Binding residue (original residue number in PDB): P13 R15 Q16 W17 F26 S28 R30 A31 N34 R37 R38 R56 R60 G61 H62 A63 A64 R66 R67 F71 I74 H94
• Binding residue (residue number reindexed from 1): P2 R4 Q5 W6 F15 S17 R19 A20 N23 R26 R27 R45 R49 G50 H51 A52 A53 R55 R56 F60 I63 H83

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qh6, PDBe:7qh6, PDBj:7qh6
• PDBsum: 7qh6
• PubMed: 35177605
• UniProt: Q9BQC6|RT63_HUMAN Large ribosomal subunit protein mL63 (Gene Name=MRPL57)