Structure of PDB 5mps Chain o Binding Site BS01

Receptor Information
>5mps Chain o (length=313) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTKSELKRRRKTRKGDGPWGSWSIRNYPGHPEGTTALKFLPKTGHLILSG
GNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVK
IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSE
NQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI
SDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS
SAGYGISLRYICSGDSKSRLFTWDWNTSRLLNNINKPITQVDWHPQETSK
VICSGAAGKIYVC
Ligand information
>5mps Chain I (length=34) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guaugucuaaaguuaugcucuuauuuacuaacaa
..................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5mps Structure of a spliceosome remodelled for exon ligation.
Resolution3.85 Å
Binding residue
(original residue number in PDB)		Y350 K374
Binding residue
(residue number reindexed from 1)		Y219 K243
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000386 second spliceosomal transesterification activity
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000348 mRNA branch site recognition
GO:0000350 generation of catalytic spliceosome for second transesterification step
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0034399 nuclear periphery
GO:0071013 catalytic step 2 spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5mps, PDBe:5mps, PDBj:5mps
PDBsum5mps
PubMed28076345
UniProtP40968|PRP17_YEAST Pre-mRNA-processing factor 17 (Gene Name=CDC40)

[Back to BioLiP]