Structure of PDB 8oz0 Chain n Binding Site BS01

Receptor Information
>8oz0 Chain n (length=142) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLT
KRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGL
DNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT
Ligand information
>8oz0 Chain W (length=1716) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgccuacuuggauaacuguggu
aauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggg
gaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgca
cgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuu
cgaugguagucgccgugccuaccauggugaccacgggugacggggaauca
ggguucgauuccggagagggagccugagaaacggcuaccacauccaagga
aggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacg
aaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucc
acuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguua
aaaagcucguaguuggaucuugggagcggccccgccccucucggcggccc
gaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgc
cuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuugu
ugguuuucggaacugaggccaugauuaagagggacggccgggggcauucg
uauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccaga
gcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgga
gguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccg
accggcgaugcggcggcguuauucccaugacccgccgggcagcuuccggg
aaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacu
uaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaau
uugacucaacacgggaaaccucacccggcccggacacggacaggauugac
agauugauagcucuuucucgauuccgugggugguggugcauggccguucu
uaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucu
ggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuu
cuuaagggacaaguggcguucagccacccgagauugagcaauaacagguc
ugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcu
cagcgugugccuacccuacgccggcaggcgcggguaacccguugaacccc
auucgugauggggaucggggauugcaauuauuccccaugaacgaggaauu
cccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuug
uacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucg
gaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacu
ugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaacc
ugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<...<....<.....<<..........>>....>.>.......<<...
.....<<<.<....<<...<.<<<<...........<<.....<<.<<..
.....>>.>>......>>.........<<<<...<<<<........>>>>
...>>>><<..<<<<<.............>>>>>......>>....<<<.
.<<<......>>>.>>>..>>>>.>...>>..>.>>>.<<<....<<<..
..<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<..
..>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>
.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>
>.>.....<..<<<<<<............>>.>>>>...>......<<..
<...........>..>>.........<<<<<((....<.<<<<.....<<
..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.
....<.<<...<<<.<<.....<<..........>>.<<...........
..>>...<<<<<<.<.......<<...<.......>.<<<<.......>>
>>...>>......>.>>>..>>>........<.<<.<<<..<<.......
........>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<
..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......
<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<
<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.
<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<.
.))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>
>..)))).]<<<...<<<<<<<..<<..<<<<<..<<<.<<<<<<.....
.<<........>>..........<<<<<......<<<<<<.......<<.
<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<..
..<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<.
......<<<<...<<<<<<<<<<<.......>>>>.>>>>.....>>>..
.>>>.>......<<<<<.....>>>>>........>>>....>>>.>>>.
....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<..<<..
......<.......<<<.<<<<....>>>>.>>>....>.........>>
..>>......<.....<<<<<..........>>>>>.....>.....>>>
>>.....<<<<<<<<.......>>>>>>>>......>>...>>.>>>>>.
>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<.
..<<<<<.......................>>>>>...>>.>>>>..>>>
.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>
>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oz0 The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R24 K25 F28 G35 V36 R38 R39 W82 F83 N85 R86 Q87 K88 H120 H125 R130 V131 R132 G133 Q134 H135 T136 K137 T139 R141 R144 T145
Binding residue
(residue number reindexed from 1)		R21 K22 F25 G32 V33 R35 R36 W79 F80 N82 R83 Q84 K85 H117 H122 R127 V128 R129 G130 Q131 H132 T133 K134 T136 R138 R141 T142
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8oz0, PDBe:8oz0, PDBj:8oz0
PDBsum8oz0
PubMed38287194
UniProtP62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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