Structure of PDB 8etg Chain n Binding Site BS01

Receptor Information

>8etg Chain n (length=416) Species: 4896 (Schizosaccharomyces pombe)

ARVKQKGKAGAARIYITRNQALKKLQLTLADFRRICILKGVYPREPKNKK
KANKGSTAPVTFYYTKDIQYLLHEPIVQKFREYKVFARKLSKALGKGELE
TAKRLEARKPTYSLDHIIKERYPTFHDALKDIDDALSMLFLFSTMPVTDK
IGAATVANCERLCAEFQHYVIRSNSLRKAFLSIKGIYYQAEIFGEQITWI
VPYKFAQSVPTDVDFRIMHTFLEFYQALMGFVNFKLYNTLGLRYPPKIDV
AKSESAAGLAAYELENTSLFSNFTFFLSREVPRFSLEFVIRAFGGKVGWD
PILGSGSPFSESDPVITHHICDRPHISQKYEGRIYIQPQWVYDSINKGIL
ERTDLYACGATLPPHLSPFVEEKEAKELSKMMMSNKQRKLYSKLKNENSK
NENYNNALRNRKRDIE

Ligand information

>8etg Chain 1 (length=2018)

uugaccucaaaucagguaggacuacgcgcugaaaauaagcgcaggaaaag
aaaauaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuu
gaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcu
gcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagag
agggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuu
ucgaagagucgaguugugcagcucuaaauggguggucaucuaaagcuaaa
uauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaa
gaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagc
auuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaaggg
aagguggcuguuuauagcccuuguuguaauacguccacuggggacugagg
acugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgu
ccacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaac
ccauccgcgaaaugaaagugaggugggaacgcccuuguggcgugcaccau
cgaccguaagagcauagcuguugggacccgaaagauggugaaaccaucua
guagcugguuccugccgaaguuucccucaggauagcagaaacucagauca
guuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaag
cagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaau
guacgcucaucagaagaaaagguguuaguucaucuagacagcaggacggu
ggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccg
aaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccu
caccgucuggguuaggaagcucagacgaguaggcaggcguggagguuugu
gacgaagccuugggcgugagccugggucgaacagccucuagugcagaucu
ugguggaaguagcuucaaaugagaacuuugaagacugaaguggggaaagg
uuccaugugaacagcaguuggacauggguuagucgauccuaagagauagg
gaagcuccguaugaaaggcacgauuuuucgugccuaucgagggaauccgg
uuaauauuccggaaccagaagguggaauacggcaacguaaaugaaguugg
agacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaacc
auuacccugacuaggguaugguguuuggaagaguucagcgccucaugcug
aauccggugcgcucucgacggccaaaauccaacggaaguuuucacaucug
gucguacucuccaaggugaacagccucuaguugauagaacaauguagaua
agggaagaaugggcccacugucccuaucuacuaucuagcgaaaccacagc
cuggggggccaggcaaaaucagcggcuuguggcagccaagcgcgacguug
cucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaccca
cuaauagggaacgugagcuggccuacugaugaagugucgucgcaauggua
auucaacuuaguacgagaggaaccguugauucagaucauugguauuugcg
gcugccugacaaggcaaugccgcggagcuaucaucugcuggauaacggcu
gaacgccucuaagccagaauccgugccagaaagcgacgauuuguauaaaa
auagagguaggcuacucuccuguaucguagaagaugggcgaugguugaug
aaacggaaguguuuuauugacuuguccaugaaauuccagaauccauugca
uacgacuuuaauguggaacgggguauuguaagcagcugcugagauuaagc
cuuuguucccaagauuug

........................<<<<<<.......>>>>>.>......
...<<....>>..<<<<<......<..>.....>>>>>..<<<..<<...
....<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.
<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((.....
.<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.
>>........<<<<<<..>>>>>>.....<<<<<..>>>>>..>>>....
..............................<<....>>............
...<<<<....>>>>..................................<
<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<........<<<<<<<
.................>>>>>>>.......>>>>>.>>>>>>>>>>...
.....<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<
..>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>
>>...>>>...<<....>>..<<<<<..<<<<<.....>>>>>...>>>>
>.<<.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...>>>>>>..
....>.>>..<<<<<<....<..<<....>>..><<<<<<<<<<...<<<
.<<<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....
>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....
<<<<<<.....<<......<<<.<<<<<<<<<<.......<<<<<.<<..
..<<.........>>....>>.........<<......>>...>>>>>..
.>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>
>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<
......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>
>>>><<.....<<<<<<<<.......>>>>>><<<<.....<<<...<<.
..<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<
<....>>>........<<<<<<......>>>>>>..>>..>>...<<<<<
........>>>>>))<<<<..<<<<...<<<....>>>.......<<<<<
<...<<<<.<<<<<<<.<<<<<<<<<<.......>>>>>>....<<<<..
..<<<<<<<..>>>>>>>.....>>>>.....<<<<<<<<.....>>>>>
>>>>>>>...>>>>>>>.>>>>.....>>>>>>......>..>>>.>>>>
>>>>..>>.>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<
.<<.......<<..>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<....>>>>>....<<<<<.<.......<<<<<...<..>...>>>>
>.<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>
.....>>>>.......>>>>...>.>>>>>......<<<<<<<..<<<<.
<.<<<<<.................>>>>>.><<<<<...<<<<....<<<
<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<
...........>>>>....>>>>.>>>>....>>>>>>>.....<<....
...<<<<<.<..>>.>>>>....>>........<<<<<....<<<<<<<<
<<<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.....
........>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>
>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8etg Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): A2 R3 V4 K5 K7 A12 R19 N20 Q21 K24 T29 L30 A31 R34 R35 K48 K51 K52 P60 A88 R89 S92 K93 K151 D215 R217 I218 H220 T221 E224 S566
• Binding residue (residue number reindexed from 1): A1 R2 V3 K4 K6 A11 R18 N19 Q20 K23 T28 L29 A30 R33 R34 K47 K50 K51 P59 A87 R88 S91 K92 K150 D214 R216 I217 H219 T220 E223 S384

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0043021 ribonucleoprotein complex binding

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0030687 preribosome, large subunit precursor
• GO:0070545 PeBoW complex

External links

• PDB: RCSB:8etg, PDBe:8etg, PDBj:8etg
• PDBsum: 8etg
• PubMed: 36423630
• UniProt: O60164|PESC_SCHPO Pescadillo homolog (Gene Name=ppp1)