Structure of PDB 7sfr Chain n Binding Site BS01

Receptor Information
>7sfr Chain n (length=60) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKKALVNKAAGKPRFAVRAYTRCSKCGRPRAVYRKFGLCRICLREMAHAG
ELPGVQKSSW
Ligand information
>7sfr Chain a (length=1519) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacac
augcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgg
gugaguaacacgugggugaucugcccugcacuucgggauaagccugggaa
acugggucuaauaccggauaggaccacgggaugcaugucuugugguggaa
agcgcuuuagcggugugggaugagcccgcggccuaucagcuuguuggugg
ggugacggccuaccaaggcgacgacggguagccggccugagagggugucc
ggccacacugggacugagauacggcccagacuccuacgggaggcagcagu
ggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcguggg
ggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccg
gguucucucggauugacgguagguggagaagaagcaccggccaacuacgu
gccagcagccgcgguaauacguagggugcgagcguuguccggaauuacug
ggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacg
gcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggg
gagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaa
caccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcga
aagcguggggagcgaacaggauuagauacccugguaguccacgccguaaa
cgguggguacuagguguggguuuccuuccuugggauccgugccguagcua
acgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaa
aggaauugacgggggcccgcacaagcggcggagcauguggauuaauucga
ugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuag
agauaggcguucccuuguggccugugugcagguggugcauggcugucguc
agcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuu
gucucauguugccagcacguaaugguggggacucgugagagacugccggg
gucaacucggaggaagguggggaugacgucaagucaucaugccccuuaug
uccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugcc
gcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucu
gcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaac
gcugcggugaauacguucccgggccuuguacacaccgcccgucacgucau
gaaagucgguaacacccgaagccaguggccuaacccucgggagggagcug
ucgaaggugggaucggcgauugggacgaagucguaacaagguagccguac
cggaaggugcggcuggauc
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<
.<<<..<<<..<<.<..<<.<<<......>>..>>>>..>>>>>......
<<........<<<<<<<..<<...<<<<<<<<<<<<..<..<<<<<....
..>>>>>.....>>>>>.....<<<<<<<<<<....>>>>>>>>>>....
.<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<
<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>
>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>
>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<
<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<
.......>.>>>>>.......>>>>>....>..<<<<<(((...<<<<<.
....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........
<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<
<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<
<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...
........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>..
..<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>......
....<<<<<<..<<<<<<<<<<.<........>>>>>>>>>>>...<<..
))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..
)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<.
.......>>..........<<<<<<<.......<<<<<..<<<<.<.<..
..>.>.>>>>............>>>>>..<<<.<<<..<<<<<<......
.<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<
.<<<<<<....<...<<<......>>>.>.....>>>>>>.....<<<<<
.....>>>>>........>>>>.........>>>...>>>>>>>>>...>
>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<
....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<.
.......>>>>>>>....>.....>>>>>>....<<<<<<<.........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<
<<..<<<<<<..<<<<....<.<<<<..<<<..<<....>>.>>>.>>>>
.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<
<....>>>>>>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7sfr Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		A2 K3 K4 L6 N8 K9 F16 V18 R19 Y21 C27 R29 R31 A32 V33 Y34 R35 R41 I42 R45 S60 W61
Binding residue
(residue number reindexed from 1)		A1 K2 K3 L5 N7 K8 F15 V17 R18 Y20 C26 R28 R30 A31 V32 Y33 R34 R40 I41 R44 S59 W60
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7sfr, PDBe:7sfr, PDBj:7sfr
PDBsum7sfr
PubMed36827973
UniProtP9WH57|RS14Z_MYCTU Small ribosomal subunit protein uS14B (Gene Name=rpsZ)

[Back to BioLiP]