Structure of PDB 7ase Chain n Binding Site BS01

Receptor Information

>7ase Chain n (length=225) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SNDLYALLKRITRQEVERRMIEHEQLRQKQQRVPQVERFLDATSKTGSSG
SSGGGGNKATEEGCGYNYSVMLRRLFFALNRNKESSAMTERNRLPEPKLE
KIGKKKVIITNFGRICQAFNRPIQDVKDYIEKELSVGGNLDSNDALILKY
EIQKSTAFDNILYKYLDEFVKCNSCHKIDTTLTKEGRRMELRCNWCTATR
TVQAVGSATYSAQVGKRSKARLQAM

Ligand information

>7ase Chain 1 (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agcaccguggcgcaguggaagcgcgaugggcucauaacccauaggacguu
ggaucgaaaccaaccggugcuacca

<<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>>....

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7ase Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Resolution	3.33 Å
Binding residue (original residue number in PDB)	G219 N255 D257 R303
Binding residue (residue number reindexed from 1)	G103 N139 D141 R187

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003729	mRNA binding
GO:0003743	translation initiation factor activity
GO:0031369	translation initiation factor binding

	Biological Process
GO:0001731	formation of translation preinitiation complex
GO:0001732	formation of cytoplasmic translation initiation complex
GO:0006412	translation
GO:0006413	translational initiation

	Cellular Component
GO:0005850	eukaryotic translation initiation factor 2 complex

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External links

PDB	RCSB:7ase, PDBe:7ase, PDBj:7ase
PDBsum	7ase
PubMed	33357443
UniProt	Q4DH88

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