Structure of PDB 8p2h Chain m Binding Site BS01

Receptor Information
>8p2h Chain m (length=135) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTINQLVRKPRQSKIKKSDSPALNKGFNSKKKKFTDLNSPQKRGVCTRVG
TMTPKKPNSALRKYARVRLSNNIEINAYIPGIGHNLQEHSVVLVRGGRVK
DLPGVRYHIVRGALDTSGVDGRRQGRSLYGTKKPK
Ligand information
>8p2h Chain a (length=1534) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaaua
caugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcgg
cggacgggugaguaacacguggauaaccuaccuauaagacugggauaacu
ucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaa
aagugaaagacggucuugcugucacuuauagauggauccgcgcugcauua
gcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccu
gagagggugaucggccacacuggaacugagacacgguccagacuccuacg
ggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagca
acgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagg
gaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucag
aaagccacggcuaacuacgugccagcagccgcgguaauacguagguggca
agcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaa
gucugaugugaaagcccacggcucaaccguggagggucauuggaaacugg
aaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaa
ugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucug
uaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacc
cugguaguccacgccguaaacgaugagugcuaaguguuagggggccccuu
agugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaa
gguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaug
ugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuu
ugacaacucuagagauagagccuuccggacaaagugacagguggugcaug
guugucgucagcucgugucgugagauguuggguuaagucccgcaacgagc
gcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugac
ugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugcc
ccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcag
cgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauu
guagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagau
cagcaugcuacggugaauacguucccgggucuuguacacaccgcccguca
caccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggag
cuagccgucgaaggugggacaaaugauuggggugaagucguaacaaggua
gccguaucggaaggugcggcuggaucaccuccuu
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<...<<<..........>>>...>>>>.>>>>
>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<
<<<<....>>>>>>......>>>>......<<<<<<<<<<..>>>>>>>>
>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....
<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<
....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....
>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>
.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<
.......<.<<<<<<<........>>>>>>>.>........>>>>>>...
>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>.
.>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<
<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>
>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......
>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>
>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>
>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>
>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....
>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<
<<<<......<<........>>..........<<<<<<<......<<<<<
<......<<<<....>>>>...........>>>>.>>.<<<.<<<..<<<
<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>
.....<<<<.<<<<<<<..<<..<<<......>>>>>...>>>>>>>...
..<<<<<.....>>>>>........>>>>.........>>>...>>>>>>
>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<
<...<<<....>>>...>>....>>>.....>>>>>>>......<....<
<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..
.......>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>
>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<
<<<<<<<<....>>>>>>>>>.............
Receptor-Ligand Complex Structure
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PDB8p2h Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric hybrid state
Resolution2.49 Å
Binding residue
(original residue number in PDB)
P2 T3 N5 Q6 R9 R12 Q13 S14 K15 K18 S19 N29 K31 K32 L38 N39 S40 P41 Q42 K43 R44 K57 N59 S60 A61 L62 R63 K64 S71 Y79 P81 G82 R96 G97 K101 D102 R107 G113 R123 R124 Q125 G126 R127 S128 L129 G131 T132 K133 K134
Binding residue
(residue number reindexed from 1)
P1 T2 N4 Q5 R8 R11 Q12 S13 K14 K17 S18 N28 K30 K31 L37 N38 S39 P40 Q41 K42 R43 K56 N58 S59 A60 L61 R62 K63 S70 Y78 P80 G81 R95 G96 K100 D101 R106 G112 R122 R123 Q124 G125 R126 S127 L128 G130 T131 K132 K133
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8p2h, PDBe:8p2h, PDBj:8p2h
PDBsum8p2h
PubMed38902339
UniProtP0A0H0|RS12_STAA8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)

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