Structure of PDB 7tns Chain m Binding Site BS01

Receptor Information
>7tns Chain m (length=201) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQPVFASPLNVEKRRLNEERALMQAQKANIQLPPNYGDMDLILFPEGSLK
NSNNTVIPQSHLKGKSVALYFADGADPKCASLLPFLLNYYRTMNEGGANQ
KIEIIFVSLDRDREAFESHRAHMPWLSIDLENPLTEILKRHFRVMKEYEV
PTYGYGSRTGVPSVIVIGSDGREAQFLPICSGLEEGDRALLRWDWRNTKF
A
Ligand information
>7tns Chain 23 (length=20) Species: 508771 (Toxoplasma gondii ME49) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LPFNAQSCYRSEYVAKPLPP
Receptor-Ligand Complex Structure
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PDB7tns Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
Resolution6.7 Å
Binding residue
(original residue number in PDB)		Y154 R164 R178
Binding residue
(residue number reindexed from 1)		Y148 R158 R172
Enzymatic activity
Enzyme Commision number 1.8.1.8: protein-disulfide reductase.
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0047134 protein-disulfide reductase (NAD(P)H) activity
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tns, PDBe:7tns, PDBj:7tns
PDBsum7tns
PubMed35121661
UniProtA0A125YMM3

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