Structure of PDB 6s13 Chain m Binding Site BS01

Receptor Information
>6s13 Chain m (length=104) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDIPREKRVVISLTYIYGIGTSTAQKILEEANVSADTRVKDLTDDELGRI
REVVDGYKVEGDLRRETNLNIKRLMEISSYRGIRHRRGLPVRGQKTKNNA
RTRK
Ligand information
>6s13 Chain a (length=1539) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaaua
caugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcgg
cggacgggugaguaacacguggauaaccuaccuauaagacugggauaacu
ucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaa
aagugaaagacggucuugcugucacuuauagauggauccgcgcugcauua
gcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccu
gagagggugaucggccacacuggaacugagacacgguccagacuccuacg
ggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagca
acgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagg
gaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucag
aaagccacggcuaacuacgugccagcagccgcgguaauacguagguggca
agcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaa
gucugaugugaaagcccacggcucaaccguggagggucauuggaaacugg
aaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaa
ugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucug
uaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacc
cugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccg
ccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacga
ccgcaagguugaaacucaaaggaauugacggggacccgcacaagcggugg
agcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugac
auccuuugacaacucuagagauagagccuuccccuucgggggacaaagug
acagguggugcaugguugucgucagcucgugucgugagauguuggguuaa
gucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguuggg
cacucuaaguugacugccggugacaaaccggaggaagguggggaugacgu
caaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggac
aauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguugu
ucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgc
uaguaaucguagaucagcaugcuacggugaauacguucccgggucuugua
cacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggag
uaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaa
gucguaacaagguagccguaucggaaggugcggcuggau
...........<.<<<<......<<<..<<<<.<..<<<<<<<.....<<
<.<<....<<..<<..<<<......................>>>..>>>>
.......<<........<<<<<<...<<...<<<<..<..........<<
..<<....>>..>>....................................
........................>..>>>>..>>.>>>>>>.<<<....
<<<....<<<<<<.......>>>>>>..>>>......>>>..<<<<<<<.
.....>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....
>>>>....>>>>>.........<<<....<<<<....>>>>..>>>..>>
.>>>>>..........................................<<
...........<<<<<........>>>>>............>>.......
......<.((.....<<<<.....<<..))>>.......>>>>..>....
>.>>>>.>>>..........<<<((.....<<<....<<<.<<<<<<..<
<....<<<.......<<<<<<.....>>>>>>.....>>>......>>.>
>>>>>...<<..<.<<....<.<<<<...............<<.......
.>>.........................<<....>>.>>>>>....>>.>
...>>...>>>....>>>....<..<<.........<<<..........>
.>>......>>..>..........<<<<<<..<<..<<<<<<<<......
>>>>>>>>..>>...<...)).>.....>>>>>>.>>>..<<.......<
<<....>>>.....>>...>>>>.>.<....<<<<<<<.....<<<<<..
<<<<<...........<<........>>..........<<<<<<<.....
.<<<<.......<<<<<....>>>>>.....<<.....>>......>>.>
>..<<.<<<...<<<.........<<<<<.<<<....>>>...<<<....
..>>>....>>>>>......<<..<....<........<<......>>..
.....>...>......<<<<.......>>>>.........>>........
.......>>>.>>>>>....>>>>>>>.........>>>>>.......<<
<<<.....<<<..........................>>>.....>>>>>
.............<.<..<..........>..>.>..........>>>>>
......<<<<<<.........>>>>>>............>>>>>>>....
>.............<<<<.<<.......<<..<<<<....<.<<<<..<<
..............>>.>>>>>....>>>>..>>.......>>.>>>>..
.............<<<<<............>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6s13 Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant.
Resolution3.58 Å
Binding residue
(original residue number in PDB)		R14 V16 T20 Y21 I22 Y23 G24 I25 G26 T27 S28 T29 A30 Q31 K32 E35 T73 Y86 R87 G88 R90 H91 G94 P96 R98 G99 Q100 K101 T102 K103 N104 N105 A106 R107 T108 R109 K110
Binding residue
(residue number reindexed from 1)		R8 V10 T14 Y15 I16 Y17 G18 I19 G20 T21 S22 T23 A24 Q25 K26 E29 T67 Y80 R81 G82 R84 H85 G88 P90 R92 G93 Q94 K95 T96 K97 N98 N99 A100 R101 T102 R103 K104
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6s13, PDBe:6s13, PDBj:6s13
PDBsum6s13
PubMed31391518
UniProtW8U8U6

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