Structure of PDB 6hkt Chain m Binding Site BS01

Receptor Information
>6hkt Chain m (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEIL
ELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQA
VLLPK
Ligand information
>6hkt Chain I (length=1122) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaccctatacgcggccgccctggagaatcccggtgccgaggccgctca
attggtcgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcc
cccgcgttttaaccgccaaggggattactccctagtctccaggcacgtgt
cagatatatacatcctgtgcatgtattgaacagccccgagaccctatacg
cggccgccctggagaatcccggtgccgaggccgctcaattggtcgtagac
agctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaac
cgccaaggggattactccctagtctccaggcacgtgtcagatatatacat
cctgtgcatgtattgaacagccccgagaccctatacgcggccgccctgga
gaatcccggtgccgaggccgctcaattggtcgtagacagctctagcaccg
cttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggggatt
actccctagtctccaggcacgtgtcagatatatacatcctgtgcatgtat
tgaacagccccgagaccctatacgcggccgccctggagaatcccggtgcc
gaggccgctcaattggtcgtagacagctctagcaccgcttaaacgcacgt
acgcgctgtcccccgcgttttaaccgccaaggggattactccctagtctc
caggcacgtgtcagatatatacatcctgtgcatgtattgaacagccccga
gaccctatacgcggccgccctggagaatcccggtgccgaggccgctcaat
tggtcgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcccc
cgcgttttaaccgccaaggggattactccctagtctccaggcacgtgtca
gatatatacatcctgtgcatgtattgaacagccccgagaccctatacgcg
gccgccctggagaatcccggtgccgaggccgctcaattggtcgtagacag
ctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccg
ccaaggggattactccctagtctccaggcacgtgtcagatatatacatcc
tgtgcatgtattgaacagcgat
Receptor-Ligand Complex Structure
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PDB6hkt Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation.
Resolution9.7 Å
Binding residue
(original residue number in PDB)		R17 R20 G28 R29 R32 R77
Binding residue
(residue number reindexed from 1)		R4 R7 G15 R16 R19 R64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hkt, PDBe:6hkt, PDBj:6hkt
PDBsum6hkt
PubMed30392928
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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