Structure of PDB 6fyx Chain m Binding Site BS01

Receptor Information
>6fyx Chain m (length=147) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INICRDNHDPFYRYKMPPIQAKVEGRGNGIKTAVLNVADISHALNRPAPY
IVKYFGFELGAQTSISVDKDRYLVNGVHEPAKLQDVLDGFINKFVLCGSC
KNPETEIIITKDNDLVRDCKACGKRTPMDLRHKLSSFILKNPPDSVS
Ligand information
>6fyx Chain 1 (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcgccguggcgcaguggaagcgcgcagggcucauaacccugauguccuc
ggaucgaaaccgagcggcgcuacca
<<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB6fyx Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		E26 R28 G29 N30 G31 R73
Binding residue
(residue number reindexed from 1)		E24 R26 G27 N28 G29 R71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005092 GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008270 zinc ion binding
GO:0031369 translation initiation factor binding
GO:0071074 eukaryotic initiation factor eIF2 binding
Biological Process
GO:0001732 formation of cytoplasmic translation initiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0042256 cytosolic ribosome assembly
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0005829 cytosol
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6fyx, PDBe:6fyx, PDBj:6fyx
PDBsum6fyx
PubMed30475211
UniProtP38431|IF5_YEAST Eukaryotic translation initiation factor 5 (Gene Name=TIF5)

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