Structure of PDB 7o9k Chain l Binding Site BS01

Receptor Information

>7o9k Chain l (length=44) Species: 9606 (Homo sapiens)

PEWLFEMNLGPPKTLEELDPESREYWRRLRKQNIWRHNRLSKNK

Ligand information

>7o9k Chain A (length=1436)

gcuaaaccuagccccaaacccacuccaccuuacuaccacaaccuuagcca
aaccauuuacccaaauaaaguauaggcgauagaaauugggcgcaauagau
auaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggac
uaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaag
gagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagc
uaaaagagcacacccgucuauguagcaaaauagugggaagauuuauaggu
agaggcgacaaaccuaccgagccuggugauagcugguuguccaagauaga
aucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuugu
aaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaa
aaccuuguagagagaguaaaaaauuuaacccauaguaggccuaaaagcag
ccaccaauuaagaaagcguucaagcucaaaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gaucacugaacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaag
guuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuacca
aaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagug
aucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguuc
agcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcg
ggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaau
gcaaacaccugcauuaaaaauuucgguuggggcgaccucggagcagaacc
caaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccuca
auugauccaauaacuugaccaacggaacaaguuacccuagggauaacagc
gcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgaug
uuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguu
caacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggu
cgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaa
uaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaac
uuaguauuauacccacacccacccaagaacaggguu

<<<.......<<<<...................................<
......>.........<.....<<.....>>....>..>>.>>.......
......<<....>>.................>>>...........<<<..
.....>>>...<.<<......>>.>.<<<<<<.........<<<.<<..<
<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<
<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>
...<<.......>>......>.>>>>......>.>>..<<<<<<....<<
<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>
>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<....
..>>>....<<<.<<<...<............<....<<<.........>
>>....>.......<<<......>>>.......................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<.........>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<......>>.>>>>.....>>>>..<
<<<...<<<<<<<<.<<.........<......<<<<<<..<<<......
...>>>...<<<<<<.............>>>>>>....<<<.....<<<<
..>>>>.<<<<<<.....>>>>>>..........>>>....>>.>>>>..
...>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>
>>>.......<<..<<<.<<.....<<<<<.<<<<<<..<<<<<.<<<<<
<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<........
.....>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>..
.......<<<....>>>............>>>>..>>>>>>>.....<<<
<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.>....<
<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<....
.>>>>>.....>>>>>..>...>>>.>>>...<<<<<<<....>>>.>>>
>....>>..>>>.>>.....<<<.<<<.................>>>.>>
><<<<<...<<<....>>>.>>>>>......<<<................
>>>.................<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o9k Structural basis for late maturation steps of the human mitoribosomal large subunit.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): P104 R115 R119 K123 I126 W127 N130
• Binding residue (residue number reindexed from 1): P12 R23 R27 K31 I34 W35 N38

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7o9k, PDBe:7o9k, PDBj:7o9k
• PDBsum: 7o9k
• PubMed: 34135318
• UniProt: Q6P161|RM54_HUMAN Large ribosomal subunit protein mL54 (Gene Name=MRPL54)