Structure of PDB 7nvr Chain l Binding Site BS01

Receptor Information
>7nvr Chain l (length=501) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQ
LFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDAL
VHAFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQI
LRHRLVTTPPQLANLTVANGRVKFRVEGEFEATLTVMGDDEILVEDKETG
SMQISFIHQLVQSRLPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGD
LVQVERYHAGKCLSLSVWNQQVHKVTIKIPLQIFHDPKIDHLSIEKLLID
SVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLH
IFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQ
RCKQSIKHLPTISSETLQLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQL
SYKYYFMSPAMALLLQQFKENIQDAFNKVLAHFVAMCDTNMPFVGLRLEL
S
Ligand information
>7nvr Chain v (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
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PDB7nvr Structures of mammalian RNA polymerase II pre-initiation complexes.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		F654 R658
Binding residue
(residue number reindexed from 1)		F493 R497
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0030374 nuclear receptor coactivator activity
GO:0042809 nuclear vitamin D receptor binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0035019 somatic stem cell population maintenance
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016592 mediator complex
GO:0032991 protein-containing complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nvr, PDBe:7nvr, PDBj:7nvr
PDBsum7nvr
PubMed33902107
UniProtO60244|MED14_HUMAN Mediator of RNA polymerase II transcription subunit 14 (Gene Name=MED14)

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