Structure of PDB 6zm5 Chain l Binding Site BS01

Receptor Information

>6zm5 Chain l (length=82) Species: 9606 (Homo sapiens)

ALKDPDVCTDPVQLTTYAMGVNIYKEGQDVPLKPDAEYPEWLFEMNLGPP
KTLEELDPESREYWRRLRKQNIWRHNRLSKNK

Ligand information

>6zm5 Chain A (length=1534)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccca
cuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauugga
ccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaa
acauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaa
uuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacu
gucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaag
gaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagc
aucaccaguauuagaggcaccgccugcccagugacacauguuuaacggcc
gcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauag
ggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaac
cagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacga
gaagacccuauggagcuuuaauuuauuaaugcaaacaguaccaaaccugc
auuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagc
aguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauuga
uccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaau
ccuauucuagaguccauaucaacaauaggguuuacgaccucgauguugga
ucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacg
auuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguu
ucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaagg
ccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagu
auuauacccacacccacccaagaacaggguuugu

<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>.<.<<<......>>>.>..<<<.<<<...<..............<..
..<<<.........>>>....>.......<<<......>>>.........
...........................>...>>>>>>........>>>>>
>...<<<<<......>>>>>.........>>>>>><......<<..<<<.
...>>><<<...<<<<........<<<<<.<<........>>.>>>>>..
....<<<...<<<<.......................>>>>.......>>
>.....<<......>>.>>>>......>>>..<<<<...<<<<<<<<.<<
.........<......<<<<<<..<<<.........>>>...<<<<<<..
...........>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><
<<<<<......>>>>>>........<...........<<<<<<.....>>
>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>
>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<
......<<<<.<<<<<<..<<<<<.<<<<<<<<....<..>......>>>
>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..
<<.....<<<..<<<<.....>>>>..>>>...........>>.......
..<<<....>>>............>>>>..>>>>>>.......<<<..<.
<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<
.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>
>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....
>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<
<...<<<....>>>.>>>>>......<<<................>>>..
....>..........<<<<.......>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zm5 Mechanism of membrane-tethered mitochondrial protein synthesis.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): P104 R115 R119 R120 R122 K123 I126 W127 H129 N130 S133
• Binding residue (residue number reindexed from 1): P50 R61 R65 R66 R68 K69 I72 W73 H75 N76 S79

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zm5, PDBe:6zm5, PDBj:6zm5
• PDBsum: 6zm5
• PubMed: 33602856
• UniProt: Q6P161|RM54_HUMAN Large ribosomal subunit protein mL54 (Gene Name=MRPL54)