Structure of PDB 5t2a Chain l Binding Site BS01

Receptor Information
>5t2a Chain l (length=81) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSV
KAIKRRRTGTGRCRYLKVVNRRIANHFKTPK
Ligand information
>5t2a Chain A (length=1603) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucugguuggugcaggaguggcgaaauucaagcgcaaagcaaacc
cguugcugaauacaacccuucaugugaguauugagccaaagaagguguua
gcccauugagccauaaaccugagcgccucaugaagcgaguagcacuguuu
gggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauaca
gaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaag
cacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaaug
gaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugu
cgggggucaaaauccggcgggcaaaagugcaagaauuuugggucuuggug
aaaugagcggaguauuugagcugugcacggccgcacgcacugguuucuuc
uccgugaugcuccauguuggcgaugaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggagauaugguug
ccaguacuucucucguacugaaagggagaugcaauaugcaucuguggugu
gcacacgucauuugcccaacaccgaccggcccuggguugcguuggagugu
gccuguuuggacccgaaagguggugaacuaugccugaacaaggugaagcc
cggggaaacccagguggaggccuguagcgaugcugacgugcaaaucgcuc
guaugauuuggguaucggagcgaaagacucaucgaaccaccuaguagcug
guucacaucgaaguuucccucaggauagcuggugcuaguagaaguauugu
gcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugca
aacaaaccgugccuuagccaacugcaaggccggaaagaaaagaauuagag
gcaccaagugggccuucuucgguaagcggagcaggcgaugcggaaugaac
cgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgug
aaaaggguguugguggauaaauccaccggccccgaaaauggaugacgcuu
aagcccaauuagugguugcccauuauuccuuugguaagggcggaaacaaa
cggagaaaguguagcccuuccgauguagauguggccuggagguuaggacg
aagcuuauggcgugagccuaagauggaccggccucuagugcagaucuugg
uuggcguagcaaagaucuaacggagauauacaacaugcaacguuggauac
uggagcggggaaggauuucgugccaacggcacucguacacgaguuguucg
gaaacugagcacaacguuauaucguuuuguuaggaaagugaagguacuga
aaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcaugu
ggg
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>
..........<..<<....<<....<......<<<<......<<<<....
...>>>>.....<<........>>......>>>><<.......((.....
>>)).......>......>>......>>>............<<<<<<<..
......>>>>>>>......<<<<<........>>>>>..>>>........
............................<<....>>..............
..<<<<....>>>>..................................((
(..<<<<<<.<<<<<<..((.<<<<.<<<<<<<<....<<<<<..<<<<<
<<<<........>>>>>>>>>...>>.>>>.........>>>>..>>>>.
.......<<<<<.....<<...<<<..<<..>>....>>>...>.>...>
>>>>.....<<<<...>>>>))..>>>>>>>>>>>>..))).<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<.<.......
.....>>>...>>>...<<....>>..<<<<<.....>>>>>...<<<<<
...<<.<<.>>.>>....>>>>><<<<<<<<<.>>>>>>.>>>...>>>>
>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<
.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>.>
>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>
>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<
<<<...<<<....<<<....<<<..>>>....>>>..>.>>...>>>>>>
>.....<<<.<<<<<.<<.....>>>>>>>>>>...........>>...>
>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>
>>>..<<<<<<<...<<<(((......<..<<<<........<.......
....<<<.<<<<<<<<<<..>>>>>>>>>>>>>..........))).>..
..>>>>.>.........>>>...>>>>>>>((((.<<<<<..........
.>>>>.........>>>>>))))....>>>>>....<<<<<<<<......
...<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>
>..............<<<<<<<..................>>>>>>>...
.................<<<<<....<<.....>>..>>>>>....<<..
........<<.<<<<<......>>>>...............<<...>>..
....>.>>..........<<<...........>....>>.>>........
...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t2a Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		T2 K3 G4 T5 T6 S7 M8 Q10 R11 H12 G13 R14 T15 H16 R24 H28 Q30 R33 A35 R41 A42 S43 R44 R45 R46 Y47 N48 W49 S50 V51 K52 K55 R56 R57 R58 T59 K79 T80
Binding residue
(residue number reindexed from 1)		T1 K2 G3 T4 T5 S6 M7 Q9 R10 H11 G12 R13 T14 H15 R23 H27 Q29 R32 A34 R40 A41 S42 R43 R44 R45 Y46 N47 W48 S49 V50 K51 K54 R55 R56 R57 T58 K78 T79
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t2a, PDBe:5t2a, PDBj:5t2a
PDBsum5t2a
PubMed27752045
UniProtP62885|RL37_LEIDO Large ribosomal subunit protein eL37 (Gene Name=RPL37)

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