Structure of PDB 8etc Chain k Binding Site BS01

Receptor Information

>8etc Chain k (length=70) Species: 4896 (Schizosaccharomyces pombe)

PRQISDIKQFLEIARRKDATSARIKKNTNKDVKFKLRCSKYLYTLVVADA
KKAEKLRQSLPPDLTVTEVG

Ligand information

>8etc Chain 1 (length=2140)

auuugaccucaaaucagguaggacuacgcgcugaacucaauaagcgcagg
aaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcuc
aaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaa
gaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacg
ucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaa
gcgcuuucgaagagucgaguuguuugcagcucuaaauggguggucaucua
aagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaa
gaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaa
agggaagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaag
aauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggg
gacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaa
uggcccgucuacacggaccaaggagucuagcaucuaugcgaguguuuggg
ugaugaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccu
ggcgugcaccaucgaccgacccggaaggguuugaguaagagcauagcugu
ugggacccgaaagauggugaacuaugccugaauagggugaagccagagga
aacucugguggaggcucguuuggguauaggggcgaaagacuaaucgaacc
aucuaguagcugguuccugccgaaggcagaaacucagaucaguuuuaugu
guaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgau
gcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucag
acaccagaaaagguguuaguucaucuagacagcaggacgguggccaugga
agucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacua
gcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucug
gguuagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcaaauauucaaaugagaacuuugaagacugaaguggggaaagguucca
ugugaacagcaguuggacauggguuagucgauccuaagagauagggaagc
uccguaugaaaaucgaaagggaauccgguuaauauuccggaaccagaagg
uggaacacggcaacguaaaugaaguuggagacgucggcgggagcccuggg
aagaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuaucc
ggagcuaggguaugguguuuggaagaguucagcgccucaugcugaauccg
gugcgcucucgacggccuugaaaauccaacggaaguuucacaucuggucg
uacucauaaccgcagcaggucuccaaggugagccucuaguugauagaaca
auguagauaagggaagucggcaaaaugggaaucgauucccacugucccua
ucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucag
cgggguggcuuguggcagccaagcgcgacguugcuggcucuuccuaucau
accgaagcagaauucgguaagcguuggacccacuaauagggagcuggguu
ccuacugaugaagugucgucgcaaugguaauucaacuuaguacgagagga
accguugauucagaucauugguauuugcggcugccugacaaggcaaugcc
gcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauc
cgugccagaaagcgacgauuguauaaaaauagaggucucuccuguaucgu
agaagaugggcgaugguugaugaaacggaaguguuuuauugacuugucca
ugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauug
uaagcagcugcugagauuaagccuuuguucccaagauuug

..........................<<<<<<..........>>>>>.>.
........<<....>>..<<<<<......<<.>>.....>>>>>..<<<.
.<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....
<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.(
(......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>
>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>.
.>>>..................................<<....>>....
...........<<<<....>>>>...........................
.......<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......
.<<<<<<<......<...>......>>>>>>>.......>>>>>.>>>>>
>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>
>>..<<<<....>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<
<.......>>>>>..>>>...<<....>>........<<<<..<<<<<..
>>>>>...>>>>..<<<<<<<<....>>>.>>>.>>....>>>>>>.>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<..
..>>>>>>>.....>>>.>>>>>>>>>...<<.......>>......>>>
>>>......>.>>..<<<<<<....<<<<<<<<<<...<<<.<<<<<<..
>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...
.<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<
..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.....
....>>....>>.........<<......>>...>>>>>...>>>>>>>>
>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<.....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<....
.<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<
<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....
>>>.........>>....>>...<<<<<........>>>>>))<<<<..<
<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<
<<<<<....(..>>>>>>....<<<<<...<<<<<<....<<<.....>>
>....>>>>>>.....>>>>>.....<<<<<<<<.....>>>>>>>>>>>
>...>>>>>>>.>>>>........>>>>>>........>>>.>>>>>>>>
..>>.....<<......>>>>>>>.<<<<..>>>>..>>>>..<<<<...
..<<<<<<<.<<.........<.....<<<<<<>>>>>>...>..>>.>>
>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<
..<<.........<<<<<<...<..>...>>>>>><<<..<<<<<..<.<
<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>>>>>.....
.>>.>>>>>.....<<<<<<<<..<<<<.<.<<<<<..............
...>>>>>.><<<<<...<<<<...<<<<<<<<<<.)....>>>>..>>>
>>>..>>>>..>>>>>.<<<<....<<<<...........>>>>....>>
>>.>>>>....>>>>>>>>...<<.......<<<<..>>>>....>>...
.....<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>
>.........<<<<<.<.............>.....<<<<<<<<<.<<<.
...<<<..>>>...>>>....>>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8etc Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): P2 R3 Q4 R17 K26 K34 K36 R38 S40 Y42 L43 T45 G71
• Binding residue (residue number reindexed from 1): P1 R2 Q3 R16 K25 K33 K35 R37 S39 Y41 L42 T44 G70

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0022618 protein-RNA complex assembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8etc, PDBe:8etc, PDBj:8etc
• PDBsum: 8etc
• PubMed: 36423630
• UniProt: Q9USR7|RL38A_SCHPO Large ribosomal subunit protein eL38A (Gene Name=rpl3801)